... and antithyroid medications may reduce oxidative stress. Tissue hypoxia participates in the pathogenesis of GO, and oxygen free radicals are involved in the typical changes of orbital tissues as reported by in vitro and clinical studies. Antioxidant agents, especially selenium, have been proposed as a therapeutic...

...Kristian Hillert Winther; Enrico Papini; Roberto Attanasio; Roberto Negro; Laszlo Hegedüs Objective: To investigate clinical practice regarding the use of selenium supplementation in patients with Hashimoto’s thyroiditis (HT) among members of the European Thyroid Association (ETA). Methods: ETA...

...Roberto Negro; Roberto Attanasio; Franco Grimaldi; Claudio Marcocci; Rinaldo Guglielmi; Enrico Papini; on behalf of AME (Associazione Medici Endocrinologi) and AACE (American Association of Clinical Endocrinologists) Italian Chapter Background: Selenium (Se) is a trace element that plays key roles...

... of this work was to ascertain whether hypothyroidism is associated with lower EPC counts and if treatment with levothyroxine (LT4) or selenium (Se) improves EPC counts compared to placebo. Methods: Hypothyroid patients (n = 100) were randomly divided into five groups to receive placebo (group A), LT4 (group B...

... measures (artificial tears, ointments and dark glasses) and control of risk factors for progression (smoking and thyroid dysfunction) are recommended for all patients. In mild GO, a watchful strategy is usually sufficient, but a 6-month course of selenium supplementation is effective in improving mild...

..., this reduction has been faster if selenium (Se) is added. Objective: The objective was to investigate whether supplementing the pharmacologic treatment with Se could change the immune mechanisms, hormone levels and/or depression and anxiety. Methods: We prospectively investigated 38 patients with initially...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Deiodinase Propylthiouracil Methimazole Selenium Inhibitor...

...Esther J. van Zuuren; Amira Y. Albusta; Zbys Fedorowicz; Ben Carter; Hanno Pijl Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT 4 ) and may provide other beneficial effects (e.g. on mood and health...

... of iodothyronine deiodinases Another common feature of the deiodinases is that they belong to the small family of 25 selenoproteins in the human genome. They contain the rare amino acid selenocysteine (Sec) encoded by UGA in their active centers [ 24 ]. The much higher nucleophilicity of selenium...

... clinical signs and symptoms of hyperthyroidism and, when associated with antithyroid drugs, induce a more rapid control of clinical manifestations and a faster achievement of euthyroidism. A large randomized clinical trial has shown that antioxidant supplementation (selenium) may also be beneficial...