...Giulia Masetti; Marian Ludgate Background: Studies from animal models of autoimmunity have highlighted the potential importance of microorganisms and their metabolic products in shaping the immune system. Summary: This review provides an introduction to the current state-of-the-art in microbiome...

...Ilaria Muller; Carla Moran; Beatriz Lecumberri; Brigitte Decallonne; Neil Robertson; Joanne Jones; Colin M. Dayan Thyroid dysfunction (TD) frequently occurs as an autoimmune complication of immune reconstitution therapy (IRT), especially in individuals with multiple sclerosis treated...

... reflect an autoimmune reaction against antigens constitutively expressed by the thyroid and by the extrathyroidal affected tissues. According to another hypothesis, the so-called Kriss’ hypothesis, soluble autoantigens released from the thyroid would reach the affected tissues, where they would become...

... absence of pigment in the skin, hair, and eyes. Reduction of melanin in the eyes results in reduced visual acuity, photophobia, and nystagmus. To our knowledge, the coexistence of albinism and thyroid autoimmune diseases has not been reported. Case Report: A 37-year-old male with OCA came to our...

.... We examined the management of subclinical hypothyroidism and chronic autoimmune thyroiditis in pregnancy among Italian and Romanian endocrinologists. Methods: Members of the Associazione Medici Endocrinologi (AME) and Romanian Society of Endocrinology (RSE) were invited to participate in a web-based...

...Elena Sabini; Ilaria Ionni; Roberto Rocchi; Paolo Vitti; Claudio Marcocci; Michele Marinò Background: Graves’ orbitopathy (GO) is believed to be the consequence of autoimmunity against antigens that are present both in the thyroid and orbital tissues. Massive release of thyroid antigens causes...

... (≥10 years) GO Graves’ orbitopathy Graves’ disease Thyroid Autoimmunity Graves’ orbitopathy (GO) is a disfiguring and disabling disease that profoundly impairs the quality of life of affected patients [ 1-4 ]. The natural history of GO is characterized by an initial phase in which...

...Ilaria Muller; Lucy S. Kilburn; Peter N. Taylor; Peter J. Barrett-Lee; Judith M. Bliss; Paul Ellis; Marian E. Ludgate; Colin M. Dayan Background: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. Objectives: We aimed to clarify...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Exophthalmos Graves’ disease Selenoprotein P Thyroid Autoimmunity Graves' disease (GD) is a prevalent thyroid disease and a leading cause of hyperthyroidism...

... thyroiditis, and in rare cases IgG4-related sclerosing disease may be an outcome. Although the cause of the lymphocytic infiltration was unknown to Hashimoto, we now know through the pioneering studies of N.R. Rose and E. Witebsky [J Immunol 1956;76:417–427] that this condition is the archetype for autoimmune...

... between thyroid variables and health-related quality of life (QoL) in patients with autoimmune hypothyroidism, using the thyroid-specific QoL questionnaire ThyPRO. Methods: In a cross-sectional study, responses to the ThyPRO from 199 outpatients with autoimmune hypothyroidism were analyzed in relation...