Purpose: Physical activity has been hypothesized to influence cancer occurrence through several mechanisms. To date, its relation with thyroid cancer risk has been examined in relatively few studies. We pooled 2 case-control studies conducted in Cuba and Eastern France to assess the relationship between self-reported practice of recreational physical activity since childhood and thyroid cancer risk. Methods: This pooled study included 1,008 cases of differentiated thyroid cancer (DTC) matched with 1,088 controls (age range 9-35 and 17-60 years in the French and Cuban studies, respectively). Risk factors associated with the practice of recreational physical activity were estimated using OR and 95% CI. Logistic regressions were stratified by age class, country, and gender and were adjusted for ethnic group, level of education, number of pregnancies for women, height, BMI, and smoking status. Results: Overall, the risk of thyroid cancer was slightly reduced among subjects who reported recreational physical activity (OR = 0.8; 95% CI 0.5-1.0). The weekly frequency (i.e. h/week) seems to be more relevant than the duration (years). Conclusion: Long-term recreational physical activity, practiced since childhood, may reduce the DTC risk. However, the mechanisms whereby the DTC risk decreases are not yet entirely clear.

Keywords:
Risk factors, Thyroid cancer, Recreational physical activity, Pooled case-control study
1.
Kilfoy BA, Zheng T, Holford TR, Han X, Ward MH, Sjodin A, Zhang Y, Bai Y, Zhu C, Guo GL, Rothman N: International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control 2009;20:525-531.
2.
Engeland A, Tretli S, Akslen LA, Bjorge T: Body size and thyroid cancer in two million Norwegian men and women. Br J Cancer 2006;95:366-370.
3.
Peterson E, De P, Nuttall R: BMI, diet and female reproductive factors as risks for thyroid cancer: a systematic review. PLoS One 2012;7:e29177.
4.
Xhaard C, de Vathaire F, Clero E, Maillard S, Ren Y, Borson-Chazot F, Sassolas G, Schvartz C, Colonna M, Lacour B, Danzon A, Velten M, Marrer E, Bailly L, Barjoan EM, Schlumberger M, Orgiazzi J, Adjadj E, Rubino C: Anthropometric risk factors for differentiated thyroid cancer in young men and women from Eastern France: a case-control study. Am J Epidemiol 2015;182:202-214.
5.
Rossing MA, Voigt LF, Wicklund KG, Daling JR: Reproductive factors and risk of papillary thyroid cancer in women. Am J Epidemiol 2000;151:765-772.
6.
Negri E, Dal Maso L, Ron E, La Vecchia C, Mark SD, Preston-Martin S, McTiernan A, Kolonel L, Yoshimoto Y, Jin F, Wingren G, Rosaria Galanti M, Hardell L, Glattre E, Lund E, Levi F, Linos D, Braga C, Franceschi S: A pooled analysis of case-control studies of thyroid cancer. 2. Menstrual and reproductive factors. Cancer Causes Control 1999;10:143-155.
7.
Brindel P, Doyon F, Rachedi F, Boissin JL, Sebbag J, Shan L, Chungue V, Sun LYK, Bost-Bezeaud F, Petitdidier P, Paoaafaite J, Teuri J, de Vathaire F: Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in native women in French Polynesia: a population-based case-control study. Am J Epidemiol 2008;167:219-229.
8.
Xhaard C, Rubino C, Clero E, Maillard S, Ren Y, Borson-Chazot F, Sassolas G, Schvartz C, Colonna M, Lacour B, Danzon A, Velten M, Buemi A, Bailly L, Marine Barjoan E, Schlumberger M, Orgiazzi J, Adjadj E, de Vathaire F: Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: a population-based case-control study. Am J Epidemiol 2014;180:1007-1017.
9.
McTiernan A, Ulrich C, Slate S, Potter J: Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 1998;9:487-509.
10.
Radak Z, Kaneko T, Tahara S, Nakamoto H, Ohno H, Sasvari M, et al: The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes. Free Radic Biol Med 1999;27:69-74.
11.
Alessio HM: Exercise-induced oxidative stress. Med Sci Sports Exerc 1993;25:218-224.
12.
Schneider S, Willis PE, Parkhouse WS: The effects of age and physical activity on cardiac mitochondrial DNA template availability. Age 1995;18:151-157.
13.
Friedenreich CM, Orenstein MR: Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 2002;132:3456S-3464S.
14.
Henderson BE, Feigelson HS: Hormonal carcinogenesis. Carcinogenesis 2000;21:427-433.
15.
McTiernan A: Mechanisms linking physical activity with cancer. Nat Rev Cancer 2008;8:205-211.
16.
Samani AA, Yakar S, LeRoith D, Brodt P: The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007;28:20-47.
17.
Vella V, Sciacca L, Pandini G, Mineo R, Squatrito S, Vigneri R, et al: The IGF system in thyroid cancer: new concepts. Mol Pathol 2001;54:121-124.
18.
Russell JP, Shinohara S, Melillo RM, Castellone MD, Santoro M, Rothstein JL: Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors. Oncogene 2003;22:4569-4577.
19.
Russell JP, Engiles JB, Rothstein JL: Proinflammatory mediators and genetic background in oncogene mediated tumor progression. J Immunol 2004;172:4059-4067.
20.
Rossing MA, Remler R, Voigt LF, Wicklund KG, Daling JR: Recreational physical activity and risk of papillary thyroid cancer (United States). Cancer Causes Control 2001;12:881-885.
21.
Robsahm TE, Hestvik UE, Veierod MB, Fagerlie A, Nystad W, Engebretsen L, Tretli S: Cancer risk in Norwegian world class athletes. Cancer Causes Control 2010;21:1711-1719.
22.
Cash SW, Ma H, Horn-Ross PL, Reynolds P, Canchola AJ, Sullivan-Halley J, Beresford SA, Neuhouser ML, Vaughan TL, Heagerty PJ, Bernstein L: Recreational physical activity and risk of papillary thyroid cancer among women in the California Teachers Study. Cancer Epidemiol 2013;37:46-53.
23.
Kitahara CM, Platz EA, Beane Freeman LE, Black A, Hsing AW, Linet MS, Park Y, Schairer C, Berrington de Gonzalez A: Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies. Cancer Causes Control 2012;23:463-471.
24.
Kolonel LN, Hankin JH, Wilkens LR, Fukunaga FH, Hinds MW: An epidemiologic study of thyroid cancer in Hawaii. Cancer Causes Control 1990;1:223-234.
25.
Leitzmann MF, Brenner A, Moore SC, Koebnick C, Park Y, Hollenbeck A, Schatzkin A, Ron E: Prospective study of body mass index, physical activity and thyroid cancer. Int J Cancer 2010;126:2947-2956.
26.
Schmid D, Behrens G, Jochem C, Keimling M, Leitzmann M: Physical activity, diabetes, and risk of thyroid cancer: a systematic review and meta-analysis. Eur J Epidemiol 2013;28:945-958.
27.
Kabat GC, Kim MY, Thomson CA, Luo JH, Wactawski-Wende J, Rohan TE: Anthropometric factors and physical activity and risk of thyroid cancer in postmenopausal women. Cancer Causes Control 2012;23:421-430.
28.
Meinhold CL, Ron E, Schonfeld SJ, Alexander BH, Freedman DM, Linet MS, Berrington de Gonzalez A: Nonradiation risk factors for thyroid cancer in the US Radiologic Technologists Study. Am J Epidemiol 2010;171:242-252.
29.
Clavel-Chapelon F, Guillas G, Tondeur L, Kernaleguen C, Boutron-Ruault MC: Risk of differentiated thyroid cancer in relation to adult weight, height and body shape over life: the French E3N cohort. Int J Cancer 2010;126:2984-2990.
30.
Lence-Anta JJ, Xhaard C, Ortiz RM, Kassim H, Pereda CM, Turcios S, Velasco M, Chappe M, Infante I, Bustillo M, Garcia A, Clero E, Maillard S, Salazar S, Rodriguez R, de Vathaire F: Environmental, lifestyle, and anthropometric risk factors for differentiated thyroid cancer in Cuba: a case-control study. Eur Thyroid J 2014;3:189-196.
31.
Cust AE, Smith BJ, Chau J, van der Ploeg HP, Friedenreich CM, Armstrong BK, Bauman A: Validity and repeatability of the EPIC physical activity questionnaire: a validation study using accelerometers as an objective measure. Int J Behav Nutr Phys Act 2008;5:33.
32.
Brantsaeter AL, Owe KM, Haugen M, Alexander J, Meltzer HM, Longnecker MP: Validation of self-reported recreational exercise in pregnant women in the Norwegian Mother and Child Cohort Study. Scand J Med Sci Sports 2010;20:e48-e55.
© 2016 European Thyroid Association Published by S. Karger AG, Basel
2016
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