...L. Dumont; E. Dagher The hemodynamic benefits and pulmonary vascular selectivity of amrinone, dobutamine and amrinone + dobutamine were assessed in a canine model of vasoconstrictive pulmonary hypertension. Dogs were equipped with central and peripheral catheters and with an electromagnetic flow...

...E. Dagher; L. Dumont; C. Chartrand; G. Blaise The pulmonary vascular and systemic effects of PGE 1 were studied in a canine model of pulmonary hypertension. Systemic arterial, central venous and pulmonary arterial pressures were monitored and an electromagnetic flow probe was placed around...

...M. Welte; B. Zwissler; H. Habazettl; K. Messmer Intravenous prostacyclin (PGI2) is a potent pulmonary vasodilator in pulmonary hypertension. However, dose-dependent systemic vasodilation, an increase in intrapulmonary shunt and hypoxemia limit its clinical application. Recently, inhaled nitric...

...J.L. Vincent; J. Goldstein; M. Domb; H. Lignan Serotonin can induce pulmonary hypertension, hypoxia and bronchoconstriction, and ketanserin has been shown to reverse these effects on various experimental models of acute respiratory failure. In the present study, the hemodynamic and gasometric...

... and Health, Institute for Inhalation Biology, and Focus-Network: Aerosols and Health, Neuherberg, Germany Key Words Inhalation therapy Prostacyclin Aerosol Pulmonary hypertension Vasodilators Myocardial contraction Abstract Inhaled prostacyclin (PGI2) aerosol induces selective pulmonary...

...G. Kemming; O. Habler; M. Kleen; H. Kisch-Wedel; M. Welte; B. Zwissler Today, the technique to directly administer vasodilators via the airway to treat pulmonary hypertension and to improve pulmonary gas exchange is widely accepted among clinicians. The flood of scientific work focussing...