...-enhanced CT images. Portal vein embolization Liver microcirculation Oxygenation Liver regeneration Liver atrophy and hypertrophy Preoperative portal vein embolization (PVE) is used to induce hepatic hypertrophy with the aim of increasing future remnant liver volume and function, allowing...

..., liver regeneration was monitored by conventional laboratory tests and the novel noninvasive maximum liver function capacity (LiMAx) test with a follow-up of 4 weeks. Results: Partial hepatectomy significantly impaired liver function according to conventional liver function tests as well as LiMAx in all...

.... Portal vein Embolization, therapeutic Liver regeneration Portography Hepatectomy Preoperative portal vein embolization (PVE) is an established therapy used to increase the volume of the future remnant liver left in place before major hepatectomy [ 1 ], thus reducing the risk of postoperative...

...Anne Andert; Hamid P. Alizai; Tom Florian Ulmer; Christoph Heidenhain; Patrick Ziegler; Tim H. Brümmendorf; Ulf Peter Neumann; Fabian Beier; Christian D. Klink Background: The aim of this study was to investigate telomere length in hepatocytes as a biomarker for liver regeneration after partial...

... criteria, or ISGLS grade C criteria [ 17-19 ]), and there was no 90-day mortality. Associating liver partition and portal vein ligation for staged hepatectomy Colorectal liver metastases Future liver remnant Liver regeneration Portal vein occlusion Associating liver partition...

...Patrick Hamid Alizai; Lea Bertram; Daniela Kroy; Julia Kummer; Anne Andert; Ulf Peter Neumann; Tom Florian Ulmer; Athanassious Fragoulis Background: Liver regeneration requires the formation of new blood vessels. Endothelial cell proliferation is stimulated by vascular endothelial growth factor...

... regeneration. We hypothesized that argon inhalation prior to partial hepatectomy (70%) has a positive effect on the initiation of liver regeneration in rats. Methods: Partial hepatectomy (70%) with or without inhaled argon (50 vol%) was performed for 1 h. Liver tissue was harvested after 3, 36, and 96 h...

... understanding of underlying mechanisms and for enhancing patient safety. Summary: Until recently, only 8 animal models have been created with the purpose to mimic ALPPS-induced liver regeneration. From these 7 are rodent (6 rat and 1 mouse) models, while only 1 is a large animal model, which uses pigs. In case...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatocytes Liver regeneration Bioengineering Differentiation...

..., these results were contrary to the general knowledge about physiological mechanisms of liver regeneration according to which changes in portal perfusion have an influence on liver regeneration. The aim of this study was to investigate whether segmental embolization of the hepatic artery can induce...

... induced by 70% PHx seemed to counteract the local atrophy after a simultaneously performed rPVL, leading to a low but prolonged regenerative response of the portally deprived liver lobe. This observation supports the conclusion that portal flow is not necessary for liver regeneration. The persisting...

... is formed by an understanding of the mechanisms of PVO-induced liver regeneration, mainly obtained from animal studies. The aim of this review is to give a comprehensive overview of the relevant animal models of PVO and to discuss the main characteristics of triggered liver regeneration, including...

...Weiwei Wei; Olaf Dirsch; Anna Lawson Mclean; Sara Zafarnia; Michael Schwier; Uta Dahmen The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models...

... postoperative liver failure [sufficient liver regeneration (SLR) group], and 9 patients with a post-PVE remK level of <0.05 did not due to insufficient FRLF [insufficient liver regeneration (ILR) group]. In the SLR group, the KICG values did not change after PVE (median, 0.144-0.146, p = 0.523); however...

...A. Taki-Eldin; L. Zhou; H.-Y. Xie; S.-S. Zheng Background/Purpose: The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation. Methods: Relevant studies were...

... synopsis of the major trends in animal research on liver regeneration from the early experiments in 1877 up to modern investigation. A major focus is placed on the translational value of experimental surgery. Methods: A systematic review of the English literature published in Medline was undertaken...

... of hepatocellular proliferation in the periportal areas. Questions unanswered involve the precise role of Kupffer cells and whether the regenerative process is characterized by a net increase in the number of lobules or by an increase in the size of the existing lobules. Conclusions: Liver regeneration has been...

... primary branches; group C, ligation of the left primary branch, followed by 2-stage PVL 7 days postoperatively. To evaluate liver regeneration, the proliferating cell nuclear antigen labeling index (LI), mitotic index (MI) in the caudate lobe and weight ratio of caudate lobe to body weight were measured...

... to the PVL lobes. Mitosis of hepatocytes on day 2 and subsequently enlarged lobules with an increased number of hepatocytes were histologic features in the PVNL liver. The AKBR was not correlated with hepatic energy charge of the liver. In conclusion, PVNL liver regenerates preceded by a decrease in EC...

..., instructions or products referred to in the content or advertisements. Liver Portal vein ligation Hepatectomy, partial Liver regeneration European Surgical Research Original Paper Eur Surg Res 1997;29:273-279 Received: Mayó, 1996 Accepted: December 19. 1996 B. Li A. Saliez L. Lambotte Laboratory o...