...L. Kaptanoglu; H.F. Kucuk; A. Yegenoglu; H. Uzun; M. Eser; C.V. Mentes; N. Kurt Aim: Postoperative intra-abdominal adhesion formation is a significant cause of morbidity. The aim of this study was to assess the effects of heparin and Seprafilm, which is considered the gold standard...

... was studied. The thrombin enzymatic activity on the subendothelium could be modulated and decreased activity was found on both types of injured vessel segments when exposed to antithrombin III (AT). An increased activity by exposing the superficially injured vessels with heparin was seen. This effect...

...U.E. Kongsgaard; A.O. Aasen; N. Smith-Erichsen; L. Bjørnskau The influence of unfractionated heparin [average molecular weight (MW) 10,000-15,000 kD] and low-molecular-weight heparin (average MW 400-600 kD) on the plasma kallikrein-kinin and the fibrinolytic system was studied in vitro...

...K. Itoh; A. Nakao; W. Kishimoto; H. Takagi Heparin is widely used in the treatment of various diseases, but the mechanisms of its biologic actions remain largely obscure. Recently, oxygen radicals, which are produced in a variety of conditions and cause tissue damage, have been implicated...

... in the oxygenator, as well as the coagulation defect originated during the surgical procedure when heparin is not administered (group I) and when it is at doses of 1 mg/kg body weight (group II) and 3 mg/kg body weight (group III). The result demonstrate that the fibrinogen deposition in the oxygenator decreased...

...S. Gupta; P.K. Jain The aim of this investigaton was to study the beneficial role of low-dose heparin in peritonitis. Peritonitis was induced in 20 dogs by the technique of Rosato and co-authors, 10 of which received low-dose heparin subcutaneously for 5 days in a dose of 100 units/kg body weight...

...C.O. Esquivel; C.-G. Björck; D. Bergqvist; S.N. Carson; U. Rothman; S.-E. Bergentz Nine glutaraldehyde-tanned human umbilical veins (GAUV) were incubated in heparin followed by storage in ethyl alcohol 50% (HAUV). These grafts were compared to five GAUV flushed with a heparinized solution without...

.... Scanning electron microscopy (SEM) was carried out to visualize any injuring effect of the media. Incubation was performed with either heparinized sodium acetate (HS), HS with 20% human serum added (HSS), or with cell culture medium with human serum, at either 4, 20 or 37 °C. Incubation with HS resulted...

...C.O. Esquivel; C.-G. Björck; D. Bergqvist; S.-E. Bergentz Tanned human umbilical vein grafts (Dardik Biograft®, Meadox®) were heparinized with tritium-labelled heparin. Two methods of heparinization were undertaken: (1) incubation with heparin followed by ethyl alcohol 50% treatment, and (2...

... of the vein near the site of the anastomosis and through which a saline solution with heparin (1 mg/kg) and penicillin (40,000 U/kg) is injected daily. The catheter emerges on top of the dog’s neck, and continuous perfusion is provided by a chronofusor. The catheter is removed after 1 month. In 30...

...H. Yuceturk; M.C. Yagmurdur; G. Gur; M. Demirbilek; B. Bilezikci; M. Turan; H. Karakayali; M. Haberal Objectives: The aim of this study was to investigate the effect of heparin on TNF-α and interleukin (IL)-6 levels and the complement system in liver regeneration in a murine model. Materials...

... in the untreated control group had been infused continuously with unfractionated heparin over 20 min with 0.2 IU/ml at a rate of 1 ml/min. Spraying the resected surface with the new fibrin sealant, Quixil, reduced bleeding to <1 ml and the post-resection bleeding times was 25 s. Bleeding time, blood loss...

... Immunoglobulin W Heparin W Salicylates W Thalidomide W Cerivastatine Abstract Drugs that are efficacious have usually also undesired side effects. When applying for marketing authorization of a drug, demonstration of a positive risk/benefit ratio is a prerequisite for approval by the competent authorities. Once...