... during shock and to develop treatment strategies. These preclinical trials are based on animal studies. Although a wide spectrum of species and experimental models are available to researchers, it is rather difficult to create an ideal animal model to study hemorrhagic shock. A major challenge...

...T. Ekman; B. Risberg; U. Bagge The rat gastric mucosa, superfused with 0.1 N HC1, was investigated following 15 min of hemorrhagic shock and 30 min of retransfusion after pretreatment with ascorbate (1 mg/l00g b.w. or 5 mg/l00 g b.w.). The size of the ischemic areas and the amount of mucosal...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 3-Hydroxybutyrate Hemorrhagic shock Ketone bodies Amino acids Alanine Eur Surg Res 1991;23:250-255 © 1991 S. Karger...

...H.J. Mäkisalo A controversy still exists on whether the liver changes to a lactate producer during hemorrhagic shock. Considerable disagreement has been reported on the question whether crystalloids or colloids should be used when treating hemorrhagic shock. The present study tries to clarify both...

...G. Zavagno; I.-W. Khan; Nicoletta Moschin; E. Pasqual; P.P. Cagol; M. Lise Gastric cold irrigation is widely used in the treatment of gastric bleeding. The purpose of this study was that of studying the effect of cooling on gastric mucosal lesions induced by hemorrhagic shock. The gastric...

...V. Vitek; C.H. Shatney; Dorothy J. Lang; R.A. Cowley 6 of 13 dogs subjected to 1 h of hemorrhagic shock (BP = 45–50 mm Hg) died during the first convalescent day. Nonsurvivors had lower baseline plasma concentrations of total and free T 4 and T 3 , as well as rT 3 , and higher T 3 uptake values...

...G. Zavagno; P.P. Cagol; P.P. Da Pian; P. Vallongo; K. Ishaq-Waris; M. Lise Transmucosal gastric potential difference (TGPD) was measured in the antrum and fundus of the stomach in two groups of rats submitted to hemorrhagic shock. In the first group the stomach contained 2 cm 3 of 0.1 N HCl...

...N. Hara; T. Furukawa; T. Yoshida; K. Inokuchi We demonstrated the effect of hemorrhagic shock with resuscitation on pulmonary fluid and protein exchange in anesthetized dogs. Lung lymph flow decreased during early shock and then increased gradually to baseline during late shock as the pulmonary...

...S.K. Cunningham; T.V. Keaveny Biochemical effects of treatment with a xanthine oxidase inhibitor (allopurinol) were investigated in an experimental hemorrhagic shock procedure. Allopurinol pretreatment abolished the increase in plasma uric acid which occurs in untreated dogs during hemorrhagic...

...P.O. Hasselgren; O. Almersjö; B. Gustavsson; T. Seeman Liver protein synthesis was studied with an in vitro method during and after 1 h of hemorrhagic shock in the dog. Protein synthesis was significantly decreased already 15 min after induction of hypovolemia and was about 50% of the initial value...

... parameters were studied: arterial blood pressure, central venous pressure, rectal temperature and pH. The association of blood transfusion with injection of isoproterenol, in adequate amounts to correct hypovolemia and to prevent vasoconstriction, is undoubtedly the best treatment of hemorrhagic shock...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Liver blood flow Liver circulation Hemorrhagic shock 133 Xe clearance method Low molecular dextran ...

...S. Nagy; T. Barankay; K. Tárnoky; G. Horpácsy Oxygen tension of thoracic duct lymph was measured continuously in dogs subjected to hemorrhagic shock. Compared to untreated controls, the group given during the development of the shock a single large dose of a potent glucocorticoid type steroid...

.... This study investigated the effectiveness of intraosseous versus intravenous infusion of hypertonic saline solution in an uncontrolled hemorrhagic shock swine model. We also tested the effect of the different sites of infusion on the intra-abdominal bleeding. Relevant hemodynamic parameters were monitored...

.... Hemorrhagic shock Immune depression Wound exudate cells Wound infection Organ blood flow Surgical Research General Subjects Eur Surg Res 2002;34:53 60 L-Arginine: A Unique Amino Acid for Improving Depressed Wound Immune Function following Hemorrhage Martin K. Angeleb Stefan M. Nitscha Rudolf A. Hatza...

... sepsis model with a hemorrhagic shock as ‘first hit’ followed by a Pseudomonas aeruginosa infusion as ‘second hit’. Materials and Methods: Twelve juvenile healthy pigs were anesthetized and hemodynamically monitored. The two-hit group (n = 6) underwent a hemorrhagic shock with a 50% reduction of the mean...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hemorrhagic shock Volume therapy Hypertonic saline Dextran Regional blood flow Microcirculation Endothelium Surgical Research World...

...A. Pape; G. Kemming; F. Meisner; M. Kleen; O. Habler In severe hemorrhagic shock, left ventricular (LV) diastolic dysfunction is an early sign of cardiac failure due to compromised myocardial oxygenation. Immediate fluid replacement or, in particular, administration of a hemoglobin-based oxygen...

... and divided into four groups: Group 1 – submitted to hemorrhagic shock restored with hypertonic saline solution (HSS); Group 2 – submitted to hemorrhagic shock without volume restoration; Group 3 – receiving only HSS, and Group 4 – control. The data analyzed were: mean arterial blood pressure, base excess...

... glycol (PEG) 4000 and BT. Materials and Methods: Under general anesthesia, laparotomy was done in rats, and PEG4000 was administered to the small intestine. We prepared models of invasive stimulation in which lipopolysaccharide (LPS) was intravenously administered, and a hemorrhagic shock model in which...