... with ciclosporin remained normoglycemic for 30 ± 3 days, whereas those transplanted either with 400 UV-irradiated islets without ciclosporin treatment or with 400 nonirradiated islets with ciclosporin treatment did not reach normoglycemia. We conclude that, in rats, multistrain islet donation is not efficient...

...K. Hirakawa; S. Ohkuma; K. Kuriyama We have examined whether or not ciclosporin A (CsA) affects structure and function of the exocrine pancreas. Male Wistar rats were treated once a day for 7 days with intraperitoneal injections of vehicle or 5, 15, 30, or 50 mg/kg of CsA. Following the CsA...

...Y.I. Kim; K. Kawano; Y. Iwao; T. Shimada; M. Kobayashi We studied the effect of ciclosporin (Cs) on rats which underwent a 90% hepatectomy. Rats were divided into two groups: group 1 (without Cs pretreatment) and group 2 (with Cs pre-treatment). Animals were given a 4-day treatment of Cs (10 mg/kg...

...S. Emre; N. Sumrani; J. Hong The effect of thalidomide on the prevention of early rejection was studied in heterotopic cardiac transplants between ACI (donors) and Lewis (recipients) rats, in combination with subtherapeutic doses of ciclosporin. Although allografts treated solely with thalidomide...

...R. Okamura; K. Tanaka; K. Asonuma; S. Uemoto; T. Katayama; M. Tanaka; H. Utsunomiya; K. Ozawa; T. Hashida; Ken-ichi Inui; R. Hori Ciclosporin (CsA) was administered subcutaneously at a dose of 3 mg/kg body weight/day from the day of operation to 14 days of liver allotransplantation in ACI rat (RTl...

...Hugh ff. S. Davies; D. St. John Collier; Sathia Thiru; Marco Decurtins; Roy Y. Calne We have examined the immunosuppressive effects of combined azathioprine (Aza) and ciclosporin (CS) in two groups of mongrel dogs receiving kidney allografts. In group 1 Aza and CS were given together daily after...

...Y.I. Kim; K. Nakashima; K. Kawano; M. Kobayashi The influence of ciclosporin (Cs) on liver regeneration was studied in rats and mice with or without thymus after two-third hepatectomy. Rats were treated at –24, 0, and +24 h posthepatectomy with oral Cs, 5, 10, or 20 mg/kg. Before hepatectomy, mice...

... with ciclosporin (Cs) and 15-deoxyspergualin (DSG), on heart allografts in presensitized rats. Heart grafts from male ACI rats were heterotopically transplanted to male LEW rats. All recipient rats were sensitized with donor-type whole blood admixed with immunoadjuvant (adjuvant complete Freund) 7 days prior...

...G. Oberhuber; T. Schmid; Rosemarie Erdkönig; W. Thaler; D. Öfner; Gabi Köröszi; G. Klima; R. Margreiter The effect of ciclosporin (CS) and methotrexate (MTX) on the development of graft-versus-host (GvH) disease was examined after small bowel allotransplantation in the rat. The drugs were tested...

...F. Filipponi; Andrea Messori; T. Valenza; Lea Paola Fabbri; F. Falcini We conducted a cross-over single-dose pharmacokinetic study in 4 pigs to measure the bioavailability of ciclosporin (CS) after intravenous and intramuscular administration. Each animal was given 5 mg/kg i.v. followed by 20 mg/kg...

... are transplanted into the spleens of rats. Two strains of rats were used: Lewis and F344. The recipients were divided into two groups, one of which received ciclosporin (Cic), while the other received no treatment. After HT, the spleens were removed periodically. The animals that did not receive Cic suffered...