Cats were subjected to regional intestinal simulated shock (regional hypotension at 30 mm Hg for 2 h during continuous vasoconstrictor nerve fibre stimulation) and the effect of treatment with large doses of methylprednisolone (30 mg/kg body weight) on intestinal blood flow and cardiac performance was studied. Methylprednisolone exerted a dilating effect on the systemic vascular bed as a whole but did not cause any significant change in flow resistance in the hypotensive intestinal vascular bed. While a pronounced depression of stroke volume, aortic blood flow and of arterial pressure occurred in the posthypotensive period of untreated animals cardiac function appeared to be very little affected posthypotensively in the treated animals, though arterial pressure and external cardiac work were reduced, probably due to the methylprednisolone-induced reduction of flow resistance. Furter, while untreated cats showed hemorrhagic lesions in the intestinal mucosa at postmortem examination, this was not the case in the methylprednisolone-treated animals. The mechanims of action is tentatively discussed.

Keywords:
Shock, Small intestine, Cardiac function, Cardiotoxic material from the intestine, Intestinal blood flow, Methylprednisolone in shock, Mucosal lesions
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© 1974 S. Karger AG, Basel
1974
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