31 dogs receiving lung allotransplants without any anticoagulative or immunosuppressive treatment were studied with regard to modification in platelets and coagulation. The results show a marked hypercoagulability and characteristic alterations of platelet morphology and number, which were indicative of formation of irreversible aggregates. The acute radiological manifestations of rejection, i.e. opacification, seems to depend more on intravascular phenomena than on perivascular and peribronchiolar cell infiltration. These results support a trial of anticoagulative and platelet aggregation-inhibitive treatment in lung transplantation in addition to immunosuppressive therapy.

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