In recent years, there have been a number of new demands and regulations which have reignited the discussion on ethics in animal-based research. In the light of this development, the present review first presents an overview of underlying core ethical questions and issues. This is followed by an outline of the current discussion on whether animals (used for experimentation) should have rights ascribed to them and whether animals need to have certain characteristics in order to be the beneficiaries of rights. The discourse on concepts of sentience and the ‘sociozoological scale' in particular is mapped out in this regard. There follows an outline of relevant ethical positions and current moral approaches to animal-based research (animal rights position, utilitarianism, ‘convergence position', intrinsic cultural value of fundamental research, ‘contractarianism', anthropocentrism, principle of the three Rs).

Keywords:
Animal ethics, Animal-based research, Animal rights, Non-human primates, Speciesism
1.
Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Text with EEA relevance. Official Journal of the European Union L 276, 20.10.2010:33-79.
2.
Basel Declaration, adopted on November 29, 2010, on the occasion of the first Basel conference ‘Research at a Crossroads'. http://www.basel-declaration.org/ (accessed November 11, 2014).
3.
Ferdowsian HR, Beck N: Ethical and scientific considerations regarding animal testing and research. PLoS One 2011;6:e24059.
4.
Hackam DG, Redelmeier DA: Translation of research evidence from animals to humans. JAMA 2006;296:1731-1732.
5.
Pound P, Ebrahim S, Sandercock P, Bracken MB, Roberts I: Where is the evidence that animal research benefits humans? BMJ 2004;328:514-517.
6.
Matthews RAJ: Medical progress depends on animal models - doesn't it? J R Soc Med 2008;101:95-98.
7.
Archibald K, Clotworthy M: Comment on ‘The ethics of animal research' by Festing & Wilkinson. EMBO Rep 2007;8:794-796.
8.
Langley G, Evans T, Holgate ST, Jones A: Replacing animal experiments: choices, chances and challenges. Bioessays 2007;29:918-926.
9.
Novikoff AB: The concept of integrative levels and biology. Science 1945;101:209-215.
10.
Festing S, Wilkinson R: The ethics of animal research. EMBO Rep 2007;8:526-530.
11.
Festing S, Wilkinson R: Response [to Archibald K, Clotworthy M]. EMBO Rep 2007;8:796-797.
12.
FRAME: Human microdosing reduces the number of animals required for pre-clinical pharmaceutical research. Altern Lab Anim 2005;33:439.
13.
Gordon N, Langley G: Comment on the talking point in EMBO reports, June 2007. EMBO Rep 2007;8:794.
14.
RDS News: GPs back animal research. London, Research Defence Society, 2006.
15.
Nordgren A: Animal experimentation: pro and con arguments using the theory of evolution. Med Health Care Philos 2002;5:23-31.
16.
Orlans FB: In the Name of Science: Issues in Responsible Animal Experimentation. Oxford, Oxford University Press, 1993.
17.
Nuffield Council on Bioethics: The Ethics of Research Involving Animals. London, Nuffield Council on Bioethics, 2005.
18.
Prescott MJ: Ethics of primate use. Adv Sci Res 2010;5:11-22.
19.
Olsson IA, Robinson P, Sandøe P: Ethics of animal research; in Hau J, Schapiro SJ (eds): Handbook of Laboratory Animal Science I, ed 3. Boca Raton, CRC Press, 2001, pp 21-37.
20.
Carlstead K: Effects of captivity on the behaviour of wild mammals; in Kleiman DG, Allen MR, Thompson KV, Lumpkin S, Harris H (eds): Wild Mammals in Captivity. Chicago, University of Chicago Press, 1996, pp 317-333.
21.
Fernström AL, Sutian W, Royo F, Westlund K, Nilsson T, Carlsson HE, et al: Stress in cynomolgus monkeys (Macaca fascicularis) subjected to long-distance transport and simulated transport housing conditions. Stress 2008;11:467-476.
22.
Olsson IA, Dahlborn K: Improving housing conditions for laboratory mice: a review of environmental enrichment. Lab Anim 2002;36:243-270.
23.
National Research Council: The Psychological Well-Being of Nonhuman Primates. Washington, National Academy Press, 1998.
24.
Rennie AE, Buchanan-Smith HM: Refinement of the use of non-human primates in scientific research. II. Housing, husbandry and acquisition. Anim Welfare 2006;15:215-238.
25.
Rudling W: Primate housing - a new approach. Anim Technol Welfare 2003;2:143-150.
26.
Waitt CD, Honess PE, Bushmitz M: Creating housing to meet the behavioral needs of long-tailed macaques. Lab Prim Newsl 2008;47:1-5.
27.
Wolfer DP, Litvin O, Morf S, Nitsch RM, Lipp HP, Wurbel H: Cage enrichment and mouse behavior - test responses by laboratory mice are unperturbed by more entertaining housing. Nature 2004;432:821-822.
28.
Wolfensohn S: Refinements in primate husbandry: a DVD teaching resource. J Med Primatol 2008;37:97.
29.
Novak MA, Suomi SJ: Psychological well-being of primates in captivity. Am Psychol 1988;43:765-773.
30.
Novak MA, Suomi SJ: Social interaction in nonhuman primates: an underlying theme for primate research. Lab Anim Sci 1991;41:308-314.
31.
Boyd Group: The Boyd Group Papers on the Use of Nonhuman Primates in Research and Testing. Leicester, The British Psychological Society, 2002.
32.
Buchanan-Smith HM, Prescott MJ, Cross NJ: What factors should determine cage sizes for primates in the laboratory? Anim Welfare 2004;13(suppl 1):197-201.
33.
Parker ST, Mitchell RW, Boccia ML: Self-Awareness in Animals and Humans. New York, Cambridge University Press, 1994.
34.
Bateson P: Assessment of pain in animals. Anim Behav 1991;42:827-839.
35.
Bateson P: Do animals feel pain? New Scientist 1992;134:30-33.
36.
Bermond B: A neurophysiological and evolutionary approach to animal consciousness and animal suffering. Anim Welfare 2001;10:47-62.
37.
Ferdowsian H: Human and animal research guidelines: aligning ethical constructs with new scientific developments. Bioethics 2011;25:472-478.
38.
Perry P: The ethics of animal research: a UK perspective. ILAR J 2007;48:42-46.
39.
Rambeck B: Mythos Tierversuch. Eine wissenschaftskritische Untersuchung. Frankfurt am Main, Zweitausendeins, 1996, pp 110-121.
40.
Birnbacher D: Dürfen wir Tiere töten? in Birnbacher D (ed): Bioethik zwischen Natur und Interesse. Frankfurt am Main, Suhrkamp, 2006, pp 222-247.
41.
Regan T, Singer P: Animal Rights and Human Obligations. Englewood Cliffs, Prentice Hall, 1989.
42.
Abbott A: French university under fire for culling macaques. Nature 2008;455:145.
43.
Prescott MJ: Finding new homes for ex-laboratory and surplus zoo primates. Lab Prim Newsl 2006;45:5-8.
44.
Kerwin AM: Overcoming the barriers to retirement of Old and New World monkeys from research facilities. J Appl Anim Welf Sci 2006;9:337-347.
45.
Seelig D, Truitt A: Post-research retirement of monkeys and other primates. Lab Prim Newsl 1999;38:1-4.
46.
Chimpanzee Health Improvement, Maintenance, and Protection Act. Public law 106-551 - Dec. 20, 2000, 106th Congress Public Law 551. Washington, US Government Printing Office, 2000.
47.
Ach JS: Transgene Tiere. Anmerkungen zur Herstellung, Nutzung und Haltung transgener Tiere aus tierethischer Perspektive; in Ach JS, Stephany M (eds): Die Frage nach dem Tier. Interdisziplinäre Perspektiven auf das Mensch-Tier-Verhältnis. Berlin, LIT, 2009, pp 33-46.
48.
Coors ME, Glover JJ, Juengst ET, Sikela JM: The ethics of using transgenic non-human primates to study what makes us human. Nat Rev Genet 2010;11:658-662.
49.
Gordon JW: A positive ethical perspective on transgenic research; in Kraus L, Renquist D (eds): Bioethics and the Use of Laboratory Animals. Ethics in Theory and Practice. Dubuque, Gregory C Benoit, 2000, pp 123-137.
50.
Schatten G, Mitalipov S: Developmental biology: transgenic primate offspring. Nature 2009;459:515-516.
51.
Olsson IA, Sandøe P: What's wrong with my monkey? Ethical perspectives on germline transgenesis in marmosets. Transgenic Res 2010;19:181-186.
52.
Call J, Tomasello M: Does the chimpanzee have a theory of mind? 30 years later. Trends Cog Sci 2008;12:187-192.
53.
Scientific Committee on Animal Health and Welfare: The Welfare of Non-Human Primates Used in Research. Health and Consumer Protection Directorate-General. Brussels, European Commission, 2002.
54.
Gómez JC: Are apes persons? The case for primate intersubjectivity. Etica Animali 1998;9:51-63.
55.
Cavalieri P, Singer P: The Great Ape Project: Equality beyond Humanity. London, Fourth Estate, 1993.
56.
Carlsson HE, Schapiro SJ, Farah I, Hau J: Use of primates in research: a global overview. Am J Primatol 2004;63:225-237.
57.
Birnbacher D: Haben Tiere Rechte? in Ach JS, Stephany M (eds): Die Frage nach dem Tier. Interdisziplinäre Perspektiven auf das Mensch-Tier-Verhältnis. Berlin, LIT, 2009, pp 47-64.
58.
Hare RM: Moral Thinking. Its Levels, Method, and Point. Oxford, Clarendon Press, 1981.
59.
Evans EP: The Criminal Prosecution and Capital Punishment of Animals. London, Faber and Faber, 1906.
60.
Dumcan IJ: The changing concept of animal sentience. Appl Anim Behav Sci 2006;100:11-19.
61.
Smith JA, Boyd KM: Lives in the Balance: The Ethics of Using Animals in Biomedical Research. Oxford, Oxford University Press, 1991.
62.
Sherwin CM, Can invertebrates suffer? Or, how robust is argument-by-analogy? Anim Welfare 2001;10:103-118.
63.
Arluke A, Sanders CR: Regarding Animals. Philadelphia, Temple University Press, 1996.
64.
Regan T: The Case for Animal Rights. Berkeley, University of California Press, 1983.
65.
Conn PM, Parker JV: The animal research war. FASEB J 2008;22:1294-1295.
66.
Conn PM, Parker JV: Winners and losers in the animal-research war. Am Sci 2008;96:184-186.
67.
Ballantyne C: California aims to crack down on animal rights extremists. Nat Med 2008;14:997.
68.
Best S, Nocella AJ (eds): Terrorists or Freedom Fighters? Reflections on the Liberation of Animals. New York, Lantern Books, 2004.
69.
Flükiger JM: The radical animal liberation movement: some reflections on its future. J Stud Radicalism 2009;2:111-132.
70.
Cressey D: Battle scars. Nature 2011;470:452-453.
71.
Singer P: Animal Liberation, ed 2. London, Cape, 1990.
72.
Birnbacher D: Absolute oder relative Grenzen der Leidenszufügung bei Versuchstieren? in Borchers D, Luy J (eds): Der ethisch vertretbare Tierversuch. Kriterien und Grenzen. Paderborn, Mentis, 2009, pp 113-124.
73.
Foëx BA: The ethics of animal experimentation. Emerg Med J 2007;24:750-751.
74.
Gärtner K: Mensch-Tier-Verantwortung. Komponenten einer Entscheidungsethik bei der Nutzung von Tieren im wissenschaftlichen Versuch; in Gärtner K (ed): Qualitätskriterien der Versuchstierforschung, Ergebnisse aus dem Sonderforschungsbereich ‘Versuchstierforschung' der Medizinischen und der Tierärztlichen Hochschule Hannover I. Weinheim, Deutsche Forschungsgemeinschaft, 1991, pp 1-26.
75.
Dreier R, Starck C: Tierschutz als Schranke der Wissenschaftsfreiheit; in Hände U (ed): Tierschutz. Testfall unserer Menschlichkeit. Frankfurt am Main, Fischer, 1984, pp 103-112.
76.
Sandøe P, Christiansen SB: Ethics of Animal Use. Oxford, Blackwell, 2008.
77.
Narveson J: Animal rights revisited; in Miller H, Williams W (eds): Ethics and Animals. Clifton, Humana Press, 1983, pp 191-204.
78.
Gärtner K, Heine G, Elsässer A: Tierversuche; in Korff W, Beck L, Mikat P (eds): Lexikon der Bioethik 3. Gütersloh, Gütersloher Verlagshaus, 1998, pp 567-572.
79.
Gross D: Allgemeine Grundlagen einer Ethik in der Zahnheilkunde; in Gross D (ed): Ethik in der Zahnmedizin. Berlin, Quintessenz, 2012, pp 27-66.
80.
Beauchamp TL, Childress JF: Principles of Biomedical Ethics. New York, Oxford, 1994.
81.
Beauchamp TL, Ferdowsian HR, Gluck JP: Rethinking the ethics of research involving nonhuman animals: introduction. Theor Med Bioeth 2014;35:91-96.
82.
Russell W, Burch R: The Principles of Humane Experimental Technique, ed 2. London, Methuen, 1959.
83.
Lloyd MH, Foden BW, Wolfensohn SE: Refinement: promoting the 3Rs in practice. Lab Anim 2008;42:284-293.
84.
National Centre for the Replacement, Refinement and Reduction of Animals in Research: NC3Rs Guidelines on Primate Accommodation, Care and Use. London, National Centre for the Replacement, Refinement and Reduction of Animals in Research, 2006.
85.
National Centre for the Replacement, Refinement and Reduction of Animals in Research: Views on the 3Rs: Survey Report 2008. London, National Centre for the Replacement, Refinement and Reduction of Animals in Research, 2008.
86.
Prescott MJ, Brown VJ, Flecknell PA, Gaffan D, Garrod K, Lemon RN, et al: Refinement of the use of food and fluid control as motivational tools for macaques used in behavioral neuroscience research: report of a working group of the NC3Rs. J Neurosci Methods 2010;193:167.
87.
Mandal J, Parija SC: Ethics of involving animals in research. Trop Parasitol 2013;3:4-6.
88.
Von der Pfordten D: Ökologische Ethik. Zur Rechtfertigung menschlichen Verhaltens gegenüber der Natur. Reinbeck, Rowohlt, 1996.
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