Until now, preservation of canine liver by hypothermia alone was not successful when the length of preservation exceeded 2 h.In this study, the canine liver was cooled by initial flushing through both portal vein and hepatic artery with the Collins’ solution supplemented with isoproterenol; storage in a commercial refrigerator at 4 °C was followed by orthotopic transplantation (27 experiments). This protocol regularly allowed successful transplantation in consecutive experiments with a preservation period up to 8 h; the viability of these livers was not greatly different from normal controls; outflow block and bleeding diathesis were not observed. Survivals longer than 5 days were obtained when the preservation period was extended from 13 to 19 h despite a bleeding diathesis which was reversed by clot-promoting agents.

Keywords:
Collins’ solution, Isoproterenol, Liver preservation, Liver transplantation
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© 1973 S. Karger AG, Basel
1973
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