A new technique to apply standard high temperature burn injuries and scalds under controlled conditions in living mice has been established. The difference between scalds and ‘dry’ heat injuries in terms of the mortality rate and the histological changes within the skin has been demonstrated. The relationship between the surface area injured and the animal’s body weight and total surface as a critical parameter with respect to survival or mortality has been established. A mechanism for toxin formation in mammalian skin after high temperature energy input has been offered. The physical and chemical characteristics of a specific burn toxin have been described. The toxic effect of the isolated product and the lethal burn injury in vivo upon kidney tissue, serum creatinine and urea have been shown. A direct correlation between the toxic compound and the mortality has been shown by protecting the animals from the toxin (a) by delayed toxin absorption; (b) by active immunization of the animals against the toxin, and (c) by serum (IgG) therapy using heterologous and homologous anti-toxic serum.

Keywords:
Thermal injuries, Lethal burns, Burn toxin, Lipid protein, In vivo burns, Scalds, Burn model
This content is only available via PDF.
© 1972 S. Karger AG, Basel
1972
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.