To examine the difference in hepatic ketogenesis during the regeneration process between cirrhotic and normal liver, arterial ketone bodies (acetoacetate and 3-hydroxybutyrate), free fatty acids and glucose concentrations and liver regeneration rate were determined at 0, 1, 2, 3 and 7 days after partial (70%) hepatectomy in thioacetamide-treated cirrhotic and normal rats. Hepatic ketone body production per unit liver was calculated by total ketone body concentration × blood volume/the remaining liver weight. The regeneration of cirrhotic liver was delayed compared with that of normal liver. In normal rats, total ketone body concentration increased on the 1st day both after hepatectomy and sham operation, and returned to the basal level thereafter. In cirrhotic rats after hepatectomy or sham operation, however, total ketone body concentration did not increase throughout the experimental period although free fatty acids level increased more greatly than in normal rats. Arterial ketone body ratio (acetoacetate/3-hydroxybutyrate) and glucose level decreased on the 1st day after hepatectomy, and recovered after the 2nd day in both cirrhotic and normal rats. Hepatic ketone body production after hepatectomy was significantly greater in normal rats than cirrhotic rats, and hepatectomy itself increased hepatic ketone body production in both rats on the 1st and 2nd postoperative days. In conclusion, hepatic ketone body production is impaired after hepatectomy in cirrhotic rats, which is possibly related to the delayed regeneration of cirrhotic liver.

Keywords:
Ketogenesis, Liver regeneration, Hepatectomy, Liver cirrhosis, Thioacetamide
This content is only available via PDF.
© 1994 S. Karger AG, Basel
1994
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.