The function of the exocrine pancreas was studied in rats in which more than 50% of the glandular tissue had been resected 1 (n = 16) or 6 (n = 20) weeks before initiation of the study. Sham-operated animals served as controls (n = 15). After partial pancreatectomy, the weight and DNA content of the remaining gland increased significantly (p < 0.001), and the digestive enzymes: DNA content ratio was temporarily elevated. The glandular tissue secreted relatively less fluid, bicarbonate and digestive enzymes than in control animals, but the outputs increased significantly (p < 0.001) during the observation period. After 6 weeks, only the fluid and bicarbonate secretion was still reduced. It is concluded (a) that the pancreatic function recovers after partial resection; (b) that the enzyme output of the remaining glandular tissue decreases temporarily; (c) that the enzyme content of the gland thereby increases, and (d) that the function of the acinar cells recovers faster than that of the ductular system.

Keywords:
Pancreas enzymes, Pancreas regeneration, Pancreas resection, Pancreas secretion
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© 1987 S. Karger AG, Basel
1987
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