Sepsis score and complement factor B (FB) have been measured in 66 severely septic surgical patients in the intensive care unit, with the aim of monitoring their clinical course and predicting their outcome. Sepsis score correlated well with clinical course. 82% of patients with initial sepsis score < 20 progressively improved and survived. Only 6% of patients with sepsis score ≧ 20 survived. FB plasma level was significantly higher (p < 0.01) in patients who subsequently survived. Two indices were identified which could predict patient outcome several days in advance with 100% accuracy: (1) the index of survival from sepsis defined as the combination of sepsis score < 20 and FB ≧ 45 mg/dl, and (2) the index of death from sepsis defined as sepsis score ≧ 20 and FB < 40 mg/dl.

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