Methylcellulose injected intraperitoneally into rats proved to give a splenomegaly combined with anemia and thrombocytopenia. The white blood cell count did not change during the treatment. The splenic parenchyma of the hypersplenic rats was then reduced by resection or splenic artery ligation to a different extent. The peripheral blood cell count was normalized after a one-third resection, whereas a more-than-two-thirds reduction of the splenic parenchyma caused infective complications in many rats. It was thus possible to treat the ‘secondary hypersplenism’ in the rat by a partial reduction of the splenic parenchyma and to avoid total splenectomy, much undesired with new immunologic knowledge.

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.