... are discussed. Eur. Neurol. 1 7: 241-246 (1978) Subacute Necrotizing Encephalopathy (Leigh) in an Adult J. Ulrich and Christa Fankhauser-Mauri Neuropathologische Abteilung des Instituts für Pathologie, Universität Basel (Prof. H.U. Zollinger), Basel Key Words. Wernicke s encephalopathy Thiamine Metabolic...

... alanine and somewhat high urinary alanine output. A diagnosis of necrotizing encephalomyelopathy was made and was confirmed when the urine was shown to inhibit thiamine pyrophosphate-adenosine triphosphate phosphotransferase. During a further relapse with increased weakness impaired conduction in limb...

... signs of ophthalmoplegia or nystagmus and ataxia which resolved within 48 h after intravenous thiamine. There were 7 women and 2 men aged 17–57 (7 below the age of 30). Precipitating events included vomiting 2, drastic weight-reducing diet 2, renal colic in a postpartum woman 1, colonic surgery 2...