... Antiplatelet drug Stroke Stroke causes Therapy failure Previous studies have reported that 30-40% of the patients admitted for an ischemic stroke are taking aspirin or another antiplatelet drug (APD) at admission [ 1 ]. This APD treatment failure can be related to many causes from inobservance...

...Dirk Dressler In some patients treated with botulinum toxin type A (BT), secondary therapy failure occurs. It can either be partial (PSTF) or complete (CSTF). One of the main causes for CSTF is the formation of antibodies against BT. We wanted to study the clinical features of BT antibody-induced...

...Dirk Dressler; Alexander Münchau; Kailash P. Bhatia; Niall P. Quinn; Hans Bigalke In some patients treated with botulinum toxin type A (BT) therapy failure occurs due to the formation of antibodies against BT (BT-AB). We investigated whether increased BT doses can overcome this form of therapy...

... samples from patients with cervical dystonia and complete or partial BT therapy failure underwent blinded simultaneous IPA and MDA testing. 27 (82%) samples showed concordant results, 17 (52%) being positive and 10 (30%) negative for both IPA and MDA resulting in a significant association...