...Jaime Kulisevsky; Henrique B. Ferraz; Antonio Suppa; Heinz Reichmann Introduction: Parkinson’s disease (PD) involves the progressive loss of dopaminergic neurons, leading to motor and non-motor symptoms that significantly impact patients’ quality of life. Safinamide modulates dopaminergic...

...Lize Chen; Qiushi Zhang; Shiduo Li; Haoran Chen; Jing Guo; Zongmao Zhao; Jing Tong Introduction: The aim of this study was to investigate the causal relationship between Parkinson’s disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE...

...Dongdong Wu; Jing He; Kai Li; Huijing Liu; Ying Jin; Wei Du; Xinxin Ma; Yunfei Long; Shuhua Li; Wen Su; Haibo Chen Introduction: Sleep disorders are common in Parkinson’s disease (PD) and significantly impact quality of life. Herein, we surveyed the incidence and severity of sleep disorders...

...Chong Xi; Xiao-Chen Bai; Ce Li; Wei-Ning Wang; Shan Tian; Yi-Lin Tang; Bo Shen; Jian Wang; Yi-Min Sun; Yu-Lian Zhu Introduction: Respiratory dysfunction in patients with Parkinson’s disease (PD) could present in the early stage and worsen in the late stages. These changes could be a factor...

...Nicky Edelstyn; Elisa Di Rosa; Alice Martini Background: This review article integrates findings from published behavioural and neuroimaging studies of impulsive-compulsive behaviours (ICBs) in Parkinson’s disease, with the aim of identifying the basic correlates of these problematic...

...Xiaoxia Yang; Zhiyun Wang Introduction: The aim of this study was to systematically explore progressive resistance training (PRT) effects in Parkinson’s disease (PD). Methods: Eligible literature was systematically searched from five electronic databases (PubMed, Web of Science, Ovid, Wanfang...

...Lulu Yao; Wei Liang; Jiahao Chen; Qian Wang; Xiaobo Huang Introduction: Constipation is a common nonmotor symptom of Parkinson’s disease (PD) and has been reported to increase the risk of developing PD. However, previous studies have yielded conflicting results. Understanding this correlation may...

...Shulan Xu; Wei Li; Qing Di Introduction: Although studies have explored some dietary patterns for Parkinson’s disease (PD), more other dietary patterns and food item under the dietary pattern are needed to investigate. This study aimed to identify more categories of dietary patterns for PD...

...Kaoru Kinugawa; Tomoo Mano; Tsunenori Takatani; Akira Kido; Kazuma Sugie Visual dysfunction is an important nonmotor symptom of Parkinson’s disease (PD). Visual hallucinations (VHs) and visuospatial dysfunctions (VSDs) are common visual dysfunctions in PD; however, the underlying mechanisms remain...

...Heinz Reichmann; Karla Eggert; Christian Oehlwein; Tobias Warnecke; Andrew J. Lees; Michael Kemmer; Patrício Soares-da-Silva Introduction: The OPTIPARK study confirmed the effectiveness and safety of opicapone as adjunct therapy to levodopa in patients with Parkinson’s disease (PD) and motor...

...Yi Zhao; Hang Qu; Wei Wang; Jiangbing Liu; Yu Pan; Zheng Li; Gang Xu; Chunhong Hu Background: The relationship between iron accumulation in the central nervous system and cognitive decline in Parkinson’s disease (PD) has not been fully elucidated. This study aimed to explore the value...

...Lei Zhang; Yiye Shao; Chunlei Tang; Zhen Liu; Dingzhong Tang; Canfang Hu; Xuelin Liang; Zhaoyang Hu; Guojun Luo Background: Parkinson’s disease (PD) is a common neurodegenerative disease affecting the elderly, but there is no blood test for PD diagnosis in the clinic currently. This study aimed...

... diseases. However, the roles of BMI and metabolic status on cognitive outcomes in Parkinson’s disease (PD) may vary and are yet to be determined. Methods: In total, 139 PD patients from the whole PD cohort in Parkinson’s Progression Markers Initiative database underwent complete laboratory measurements...

... Introduction: The Unified Dyskinesia Rating Scale (UDysRS) was developed to provide a comprehensive rating tool of dyskinesia in Parkinson’s disease (PD). Because dyskinesia therapy trials involve multicenter studies, having a scale that is validated in multiple non-English languages is pivotal...

...Sophie Bayard; Cindy Lebrun; Alexia Arifi-Rossignol; Christian Geny; Marie-Christine Gély-Nargeot; Annemarie I. Luik Background: Insomnia is a highly common sleep disorder in patients with Parkinson’s disease (PD). Yet, no screening questionnaires following the Diagnostic and Statistical Manual-5...

...Makoto Kobayashi; Satoshi Kuwabara Background: In individuals with Parkinson’s disease (PD), visually guided saccades (VGSs) reportedly reflect general motor dysfunction and cognitive impairments. However, it has not been fully elucidated whether the VGS abnormalities result from nigrostriatal...

...Sjors C.F. van de Weijer; Annelien A. Duits; Bastiaan R. Bloem; Nienke M. de Vries; Roy P.C. Kessels; Sebastian Köhler; Gerrit Tissingh; Mark L. Kuijf Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson’s disease (PD). Gamification may enhance...

...Yu Lin; Yi-Fang Zeng; Nai-Qing Cai; Xiao-Zhen Lin; Ning Wang; Jin He Introduction: Several studies have identified a number of genes associated with Parkinson’s disease (PD). Genomic rearrangements (exon dosage variations) in these genes have emerged as significant, causing mutations. However, exon...

...Onanong Phokaewvarangkul; Soradech Krootjohn; Panamet Yanthitirat; Chanawat Anan; Roongroj Bhidayasiri Introduction: Driving competency is important to evaluate among individuals with Parkinson’s disease (PD). Driving in natural situations is the preferred assessment method; thus, we used...

...Kunio Toda; Mutsumi Iijima; Kazuo Kitagawa Objective: We quantitatively evaluated the gait of Parkinson’s disease (PD) patients over a 10-m course during normal walking and during dual-task walking while performing a calculation task, and clarified which parts of white matter lesions (WML...