...Jaime Kulisevsky; Henrique B. Ferraz; Antonio Suppa; Heinz Reichmann Introduction: Parkinson’s disease (PD) involves the progressive loss of dopaminergic neurons, leading to motor and non-motor symptoms that significantly impact patients’ quality of life. Safinamide modulates dopaminergic...

... Depression Huntington’s disease Parkinson’s disease Neuropsychiatric symptoms Non-motor symptoms Apathy can be defined as a quantitative reduction of voluntary goal-directed behaviours that can be divided in 3 main domains: emotional-affective, cognitive and auto-activation deficit [ 1 ]. Each...

.... Dyskinesia Non-motor symptoms Subthalamic deep brain stimulation Effect size Health-related quality of life Although the symptomatic treatment in the early stages of Parkinson's disease (PD) is usually satisfactory, in the advanced stage, it may become challenging due to both motor- and non-motor...

... to in the content or advertisements. Rapid eye movement sleep behavior disorder Non-motor symptoms Parkinson’s disease Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream-enacting behaviors and loss of normal muscle atonia during REM sleep [ 1...

...M.S. Bryant; D.H. Rintala; J.G. Hou; S.P. Rivas; A.L. Fernandez; E.C. Lai; E.J. Protas Objective: To characterize non-motor symptoms in individuals with Parkinson’s disease (PD) who experience falls compared to those who do not fall. Methods: Fifty-four individuals with PD were studied. Thirty-six...