...Dasen Yuan; Bihui Huang; Meifeng Gu; Bang-e Qin; Zhihui Su; Kai Dai; Fu-hua Peng; Ying Jiang Introduction: Many clinical studies reported the coexistence of Alzheimer’s disease (AD) and multiple sclerosis (MS), but the common molecular signature between AD and MS remains elusive. The purpose of our...

...Marek Peterka; Martin Valis; Ondrej Soucek; Jan Krejsek; Lukáš Sobisek; Ilona Sejkorova; Blanka Klimova; Pavel Stourac; Zbysek Pavelek; Michal Novotny Introduction: Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease that secondarily leads to axonal loss...

...Alireza Emadi; Sara Halakoo; Cyrus Taghizadeh Delkhoush; Fatemeh Ehsani Introduction: Multiple sclerosis (MS) is a common neurological disorder in societies. The most common symptoms in patients with MS are gait disorders and spasticity. Pharmacological therapies have mild therapeutic influence...

...Daniela Noa Zohar; David Magalashvili; Sapir Dreyer-Alster; Chen Hoffmann; Gil Harari; Mark Dolev; Anat Achiron Introduction: MRI activity is less frequent among secondary progressive multiple sclerosis (SPMS) patients. In the current study, we aimed to identify SPMS patients with higher...

... with multiple sclerosis (MS) as they represent a vulnerable population through their treatment with disease-modifying therapies (DMTs). Infective episodes may trigger relapses and lead to deterioration of the health condition. Summary: Vaccination is an important preventive measure against infectious diseases...

...Pablo Arroyo-Pereiro; Albert Muñoz-Vendrell; Laura Bau; Elisabet Matas; Lucia Romero-Pinel; Antonio Martínez-Yélamos; Sergio Martínez-Yélamos Introduction: Prior studies have suggested that cardiovascular risk factors (CVRFs) can affect the prognosis of multiple sclerosis (MS). The aim...

... coherence tomography (OCT), and magnetic resonance imaging (MRI) measures. Methods: Sixty-four multiple sclerosis (MS) patients underwent peripapillary retinal nerve fiber layer and segmented macular layers evaluation through OCT (Spectralis, Heidelberg Engineering). Brain parenchymal fraction...

... people. Multiple sclerosis (MS) is the most common chronic immune-mediated neurological disease. Vaccinations play an important role in the therapeutic MS management. This study aimed at determining MS patients’ attitudes toward vaccinations and governmental measures before and during the SARS-CoV-2...

...Jarmila Szilasiová; Jaroslav Rosenberger; Miriam Fedičová; Pavol Mikula; Peter Urban; Zuzana Gdovinová; Marianna Vitková; Jozef Hanes; Eva Stevens Introduction: There is a need for blood biomarkers of disease activity in multiple sclerosis (MS). The aim of the study was to assess the relationship...

...Mohsen Ali Alhomoud; Abdul Sattar Khan; Iftetah Alhomoud Background: Multiple sclerosis (MS) is an inflammatory demyelinating chronic neurological disease that affects the central nervous system of young adults and their quality of life. Several studies have investigated the effects of pregnancy...

...Ozge Arici Duz; Ozlem Saatci; Ece Zeynep Karakulak; Erkingul Birday; Lutfu Hanoglu Background: Multiple Sclerosis (MS) is a neuroinflammatory, neurodegenerative, demyelinating disease that causes cognitive, olfactory, and other neurological dysfunctions. Radiologically Isolated Syndrome (RIS...

...Cihat Uzunköprü; Yesim Beckmann; Sabiha Türe Introduction: The primary aim of the present study was to evaluate the long-term efficacy of fingolimod in patients with multiple sclerosis (MS); secondary aims were to describe the safety of fingolimod with the evaluation of treatment satisfaction...

... leukoencephalopathy (PML). Little is known about seroconversion rate and time to seroconversion in relapsing-remitting multiple sclerosis (RRMS) patients treated with NAT in Poland. The aim of the study was to assess the true risk of PML, seroconversion rate, and time to seroconversion in all JCVAb-negative RRMS...

...Oscar H. Del Brutto; Robertino M. Mera; Aldo F. Costa; Patricia Silva; Victor J. Del Brutto Dawson fingers are used to differentiate multiple sclerosis (MS) from other conditions that affect the subcortical white matter. However, there are no studies evaluating the presence of Dawson fingers...

...Sai Batchu Accumulating evidence suggests M2 macrophages contribute to tissue reparation and limit inflammation in multiple sclerosis (MS). However, most studies have focused on murine models without substantial support through human MS observations. The present study aimed to quantify the relative...

...Radka Bužgová; Radka Kozáková; Monika Škutová Background: Only a few studies have been done focusing on the quality of life (QoL) of patients with multiple sclerosis (MS) as well as their family members. The aim of our research was to determine the factors that influence the QoL of MS patients...

...Mesrure Koseoglu; Mesude Tutuncu Objective: The aim of the study was to determine the risk of multiple sclerosis (MS) conversion after optic neuritis (ON) and to identify the predictive factors on conversion in Turkish patients. Methods: Patients whose first clinical attacks had been ON were...

...Eloi Magnin; Yoshimasa Sagawa; Thierry Moulin; Pierre Decavel Introduction: Cognitive impairment is frequent in persons with multiple sclerosis (PwMS) and can impact on activities of daily living. The capacity to differentiate real changes from background statistical noise induced by human...

... studies comparing the efficacy of fingolimod (FIN) and natalizumab (NTZ) as second-line therapy for relapsing-remitting multiple sclerosis (RRMS). Methods: Multicenter, observational study, in which, information of 388 patients randomly selected and treated with FIN or NTZ in routine clinical practice...

...Agata Czarnowska; Katarzyna Kapica-Topczewska; Olga Zajkowska; Renata Świerzbińska; Monika Chorąży; Joanna Tarasiuk; Joanna Zajkowska; Jan Kochanowicz; Alina Kułakowska Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that leads to inflammation...