...D. Schneider-Helmert The effects of DSIP on night sleep and on waking functions are demonstrated in double-blind studies in insomniacs, presenting influences of single dose treatments as well as of repeated injections. Moreover, a single case study describes the efficiency of DSIP on narcolepsy...

...Dietrich Schneider-Helmert The immediate effects of one week of Delta Sleep-Inducing Peptide (DSIP) administration (6 X 30 nmol/kg b.w., i.v.) and late effects after a follow-up period of one week were investigated in a sleep laboratory study. The population of 18 chronic psychophysiological...

...Dietrich Schneider-Helmert Impaired daytime functions are a significant part of chronic insomnia besides sleep disturbance. Therefore, the effects of intermediate-term delta-sleep-inducing peptide (DSIP) administration on sleep and daytime performance were investigated in 14 middle-aged chronic...

...Dietrich Schneider-Helmert Repeated injections of delta sleep-inducing peptide (DSIP) were given to a 35-year-old male narcoleptic. Effects on wakefulness and sleep were evaluated by self-reports, performance tests, multiple sleep latency test and all-night polysomnography. DSIP reduced...

...P. Dick; C. Costa; K. Fayolle; M.E. Grandjean; A. Khoshbeen; R. Tissot The hypothesis for this therapeutic use of delta sleep-inducing peptide (DSIP) was based on several animal studies conducted by Tissot. He showed that morphine, alcohol, pentobarbital as well as DSIP, when injected directly...

...Dietrich Schneider-Helmert This paper summarizes different investigations into effects of delta sleep-inducing peptide (DSIP) injections on insomnia. Two different studies showed improvement of sleep following single injections of 25 nmol/kg b.w. before sleep. Repeated administrations indicated...

...W. Larbig; W.D. Gerber; M. Kluck; G.A. Schoenenberger Experimental results suggested a modulation or ‘programming’ interaction of delta sleep-inducing peptide (DSIP) with endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine and amphetamine...

...H.E. Kaeser In an open study 7 patients with severe insomnia were treated by a series of 10 injections with the delta-sleep-inducing peptide (DSIP). In all but 1 case sleep was normalized for follow-up periods of 3–7 months. The mood and performance during the daytime improved as well. A problem...

...R. Scherschlicht; L. Aeppli; P. Polc; W. Haefely The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep. In other experiments, the effect of the oligopeptide on withdrawal jumping provoked by naloxone in morphine-dependent mice...