... were patients with at least 1 failed therapy attempt with either baclofen or tizanidine (Group 1) or at least 2 failed therapy attempts with both baclofen and tizanidine (Group 2). Summary: Of 241 patients in the intent-to-treat population, 162 and 57 patients met the criteria for Groups 1 and 2...

...Robert P. Iacono; Jennifer Linford; Ara Tourian; Reuven Sandyk Baclofen at 20–40 mg/day was used to successfully treat two post-amputation patients who developed continuous complex involuntary movements of the proximal extremity. These autonomous movements were otherwise recalcitrant to therapy...

...C.F. Terrence; G.H. Fromm; R. Tenicela Baclofen has shown analgesic properties in a number of animal studies but has failed as a conventional analgesic in the human postoperative dental pain model. In order to test baclofen’s analgesic properties in more chronic pain conditions, we selected...

...R. Sandyk A patient with neuroleptic-induced akathisia was successfully treated with a combination of baclofen (a GABA agonist) and clonazepam (a serotonergic agent). This suggests that agents bypassing the dopaminergic systems may be effective in the treatment of this distressing disorder. ©...

...R. Sandyk A 58-year-old women with long-standing hemifacial spasm experienced dramatic relief of symptomatology while receiving baclofen (Lioresal®) in a daily dosage of 37.5 mg. Clinical response was noted within 48 h and she remained asymptomatic during 12 months of treatment. No toxic or side...

...L. Steardo; A. Leo; E. Marano Baclofen (beta-4-chlorophenyl-gamma-aminobutyric acid) shows analgesic properties in rats and resembles carbamazepine and phenytoin in its effects on the spinal trigeminal nucleus of cats. We have, therefore, conducted a clinical trial in 25 subjects, 16 suffering from...

...W. Cendrowski; W. Sobczyk 25 patients with multiple sclerosis (MS) and other spastic disorders, 33 MS patients and 10 control patients with MS were given clonazepam, baclofen or placebo over a period of 5 days to 20 weeks. Both clonazepam and baclofen were significantly more effective than placebo...