...; Nicola Ticozzi; Barbara Poletti Introduction: The present study aimed at testing the longitudinal feasibility of the Montreal Cognitive Assessment (MoCA) in an Italian cohort of non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 39 non-demented ALS patients were followed-up at a 5...

...Eglė Sukockienė; Ruxandra Iancu Ferfoglia; Antoine Poncet; Jean-Paul Janssens; Gilles Allali Progressive loss of walking ability in amyotrophic lateral sclerosis (ALS) has been scarcely studied as a potential predictive factor for survival in motor neuron disease. We aimed to assess the progression...

... for spinal onset Amyotrophic Lateral Sclerosis (ALS). Identifying occurrence of ALS in patients with CSM may be challenging. We evaluated the accuracy of Awaji criteria in the diagnosis of ALS in a cohort of patients with CSM. We screened all patients attending Turin ALS Center during the 2006–2018 period...

...Antoine Pegat; Françoise Bouhour; Kevin Mouzat; Christophe Vial; Benoit Pegat; Pascal Leblanc; Emmanuel Broussolle; Stéphanie Millecamps; Serge Lumbroso; Emilien Bernard Objective: C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS). The aim of the present study...

... in amyotrophic lateral sclerosis (ALS) patients. Methods: We retrospectively analyzed relationship between clinical features and the decremental response in RNS in 184 sporadic ALS patients. Results: (1) 44.3 and 43.5% of compound muscle action potentials (CMAP) decrement were more than –10% in deltoid muscle...

...Hiroki Yamada; Takahiro Takeda; Toshiki Uchihara; Shizuko Sato; Susumu Kirimura; Yuka Hirota; Makoto Kodama; Masanobu Kitagawa; Katsuiku Hirokawa; Takanori Yokota; Shuta Toru Subicular degeneration occurs in amyotrophic lateral sclerosis (ALS) patients. However, it was unknown whether microscopic...

... was to evaluate the frequency of PMR in amyotrophic lateral sclerosis (ALS). Patients and Methods: Non-demented ALS patients ( n = 179) were recruited. Two groups of disease controls were enrolled: (a) non-demented patients with other neurological disorders (NC; n = 86, mean age 60 ± 14 years); (b) healthy...

...Raul Juntas-Morales; Nicolas Pageot; Sébastien Alphandéry; William Camu Background/Aims: To describe the use of peripherally inserted central catheter (PICC), in amyotrophic lateral sclerosis (ALS) at a later stage. Methods: Twenty-five ALS patients in the later stages of the disease underwent PICC...

...Lucio Tremolizzo; Andrea Pellegrini; Emanuela Susani; Christian Lunetta; Susan C. Woolley; Carlo Ferrarese; Ildebrando Appollonio Background: Caregivers of patients affected by amyotrophic lateral sclerosis (ALS) are involved with great determination in the treatment process since the earliest...

...Ruxandra Iancu Ferfoglia; Anne-Chantal Heritier Barras; Pierre Pollak; Jean-Paul Janssens; Pierre-Francois Pradat; Gilles Allali Objective: Gait and balance are key determinants of disease status in amyotrophic lateral sclerosis (ALS). This study aims at testing the relationship between the imagery...

... of consecutive Japanese patients with neurodegenerative diseases during the past 5 years, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), dementia with Lewy bodies, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA). Results: Out...

...Hiroo Ichikawa; Hideki Ohno; Hidetomo Murakami; Seiichiro Ishigaki; Yohei Ohnaka; Mitsuru Kawamura We investigated whether a self-rated anosognosia score can be an indicator for progression of brain atrophy in patients with amyotrophic lateral sclerosis (ALS). Scores for 16 patients were compared...

...Hiroo Ichikawa; Hideki Ohno; Hidetomo Murakami; Yohei Ohnaka; Mitsuru Kawamura Aim: To investigate whether writing errors are predictive of longitudinal brain atrophy progression in patients with amyotrophic lateral sclerosis (ALS). Methods: The frequency of writing errors in 6 ALS patients without...

...Hiroo Ichikawa; Michael W. Miller; Mitsuru Kawamura Although Charcot described amyotrophic lateral sclerosis (ALS) in the 1870s, he did not focus on language. And language problems in ALS with or without dementia were long ignored. A recent report by Caselli et al. [Ann Neurol 1993;33:200–207...

...Hiroo Ichikawa; Sotaro Hieda; Hideki Ohno; Yohei Ohnaka; Yuuki Shimizu; Masashi Nakajima; Mitsuru Kawamura The frequency of writing errors in samples from 14 patients with amyotrophic lateral sclerosis without manifest aphasia were compared with clinical background and indices from X-ray computed...

... in pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). Interleukin (IL)-15 and IL-12 are proinflammatory cytokines produced by activated blood and glial cells. They promote T cell differentiation and proliferation. Patients and Methods: We measured by ELISA serum and cerebrospinal fluid (CSF) levels...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 1997 Amyotrophic lateral sclerosis Bone mineral density Vitamin-D deficiency...

...P. Aebischer; A.C. Kato Neurotrophic factors which act on motor neurons may provide an efficient treatment for amyotrophic lateral sclerosis. In order to overcome the difficulty of administering proteins into the central nervous system, it is possible to use a gene therapy approach, i.e...

...M. Mittler; P. Vieregge; E. Reusche; K. Ogomori Clinicopathological data of a woman with a 3-year course of concurrent amyotrophic lateral sclerosis and dementia are presented. Dementia had occurred at time of onset of motor disturbances and presented as typical frontal lobe dementia. Pathology...

...Ching-Piao Tsai; Hsu-Hua Ho; Der-Jen Yen; Vinchi Wang; Kong-Ping Lin; Kwong-Kum Liao; Zin-An Wu We investigated a 69-year-old male with a clinical syndrome resembling amyotrophic lateral sclerosis characterized by fasciculation, wasting of the limb muscles and increased deep tendon reflexes...