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Keywords: Acetylcholine
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Journal Articles
Botulinum Toxin: Mechanisms of Action
Available to PurchaseSubject Area:
Neurology and Neuroscience
Journal:
European Neurology
Eur Neurol (2005) 53 (1): 3–9.
Published Online: 12 January 2005
... for understanding its therapeutic use. BT’s molecular mode of action includes extracellular binding to glycoprotein structures on cholinergic nerve terminals and intracellular blockade of the acetylcholine secretion. BT affects the spinal stretch reflex by blockade of intrafusal muscle fibres with consecutive...
