I am very grateful to Dr. Frater for his views; his analysis and discussion are very powerful additions to the paper. The cerebrospinal fluid white blood cell elevation is a very important indicator in the diagnosis of neurosyphilis and is included in the diagnostic criteria in the guidelines or consensus in regions [1‒4]. His views on the preanalytical factors of cerebrospinal fluid leukocyte data are very instructive. I strongly agree with the initiative to introduce cell counting method in detail in research, as well as measures to make laboratory results more accurate.

The author declares there are no competing interests.

No funding was received.

Duyu Ding drafted the manuscript.

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