A 54-year-old woman suffering from medial temporal lobe epilepsy underwent simultaneous recordings with intracranial electroencephalogram (EEG) and high-density scalp EEG. Interictal scalp EEG showed intermittent 2.5-Hz lateralized rhythmic delta activity (LRDA) in the right frontotemporal region, synchronous with the right hippocampal epileptiform discharges on intracranial EEG. The association between seizures and LRDA is frequency-dependent: only frequencies ≥1.5 Hz are associated with seizures . Nearly all patients with LRDA have focal injury on the side of the rhythmic activity . As our case illustrates, LRDA can correspond to irritative activity in the medial temporal lobe and could therefore be considered an interictal epileptiform abnormality (Fig. 1, 2).
We thank the patient for her participation in the research project and for agreeing to the publication of this article.
Statement of Ethics
The present research project was approved by the relevant ethics committee (Commission Cantonale d’Ethique de la Recherche, République et Canton de Genève, Switzerland). The patient gave written consent to participate and to publish the case (including publication of images).
P.D.S. and P.M. report no competing interests. S.V. and M.S. report that they are shareholders of Epilog NV. M.S. received speaker’s fees from Philips and Desitin.
This project was supported by Swiss National Science Foundation grants 163398, 167836, 169198, 170873, and 180365 (Sinergia).
P.D.S.: methodology, formal analysis, investigation, data curation, writing original draft, and visualization. S.V.: conceptualization, methodology, investigation, resources, supervision, project administration, and funding acquisition. M.S.: supervision and funding acquisition. P.M.: formal analysis, writing review, and editing.