Introduction: The aim of this study was to explore the differences in status epilepticus (SE) management among pediatric neurology, emergency medicine, and intensive care specialists in Turkey. Methods: A 22-item questionnaire regarding first-, second-, and third-line management strategies of SE including demographic characteristics and common etiologies according to the specialty of participants was mailed to 370 specialists working in Turkey. Results: A total of 334 participants (response rate 90%) comprising 136 pediatric neurologists, 102 pediatric emergency medicine specialists, and 96 pediatric intensive care specialists completed the survey. While intensive care specialists frequently managed SE due to metabolic and autoimmune reasons, the most common etiologies encountered by emergency medicine specialists were epilepsy and infections. More than half of the intensive care specialists (64.6%) reported using non-BZD antiseizure medications in the 5th minute of the seizure. Most of the neurologists (76.4%) preferred to administer intravenous (IV) levetiracetam infusion as a second-line agent. About half of intensive care specialists and neurologists tried immunomodulatory therapies in super-refractory SE. Intensive care and emergency medicine specialists were less likely to favor ketogenic diet and pyridoxine therapy for the treatment of super-refractory SE. The rate of requesting EEG monitoring to recognize nonconvulsive SE (NCSE) was found to be very low except for neurologists. Conclusion: There was no consensus among neurologists, intensive care specialists, and emergency medicine specialists in the management of SE in Turkey. Familiarity with particular antiseizure medications and the etiologies they manage seem to be the most important factors influencing the attitudes.

1.
Trinka
E
,
Cock
H
,
Hesdorffer
D
,
Rossetti
AO
,
Scheffer
IE
,
Shinnar
S
.
A definition and classification of status epilepticus: report of the ILAE task force on classification of status epilepticus
.
Epilepsia
.
2015
;
56
(
10
):
1515
23
.
2.
Gurcharran
K
,
Grinspan
ZM
.
The burden of pediatric status epilepticus: epidemiology, morbidity, mortality, and costs
.
Seizure
.
2019 May
68
3
8
.
3.
Novorol
CL
,
Chin
RF
,
Scott
RC
.
Outcome of convulsive status epilepticus: a review
.
Arch Dis Child
.
2007
;
92
(
11
):
948
51
.
4.
Eriksson
K
,
Metsaranta
P
,
Huhtala
H
,
Auvinen
A
,
Kuusela
AL
,
Koivikko
M
.
Treatment delay and the risk of prolonged status epilepticus
.
Neurology
.
2005
;
65
(
8
):
1316
8
.
5.
Messahel
S
,
Bracken
L
,
Appleton
R
.
Optimal management of status epilepticus in children in the emergency setting: a review of recent advances
.
Open Access Emerg Med
.
2022
;
14
:
491
506
.
6.
Zimmern
V
,
Korff
C
.
Status epilepticus in children
.
J Clin Neurophysiol
.
2020
;
37
(
5
):
429
33
.
7.
Abend
NS
,
Loddenkemper
T
.
Pediatric status epilepticus management
.
Curr Opin Pediatr
.
2014
;
26
(
6
):
668
74
.
8.
Vasquez
A
,
Farias-Moeller
R
,
Tatum
W
.
Pediatric refractory and super-refractory status epilepticus
.
Seizure
.
2019
;
68
:
62
71
.
9.
Lawton
B
,
Davis
T
,
Goldstein
H
,
Tagg
A
.
An update in the initial management of paediatric status epilepticus
.
Curr Opin Pediatr
.
2018
;
30
(
3
):
359
63
.
10.
Barcia Aguilar
C
,
Sánchez Fernández
I
,
Loddenkemper
T
.
Status epilepticus-work-up and management in children
.
Semin Neurol
.
2020
;
40
(
6
):
661
74
.
11.
Crawshaw
AA
,
Cock
HR
.
Medical management of status epilepticus: emergency room to intensive care unit
.
Seizure
.
2020
;
75
:
145
52
.
12.
Glauser
T
,
Shinnar
S
,
Gloss
D
,
Alldredge
B
,
Arya
R
,
Bainbridge
J
.
Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the guideline committee of the American epilepsy society
.
Epilepsy Curr
.
2016
;
16
(
1
):
48
61
.
13.
Capovilla
G
,
Beccaria
F
,
Beghi
E
,
Minicucci
F
,
Sartori
S
,
Vecchi
M
.
Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League against Epilepsy
.
Epilepsia
.
2013
54
Suppl 7
23
34
.
14.
Zhao
ZY
,
Wang
HY
,
Wen
B
,
Yang
ZB
,
Feng
K
,
Fan
JC
.
A comparison of midazolam, lorazepam, and diazepam for the treatment of status epilepticus in children: a network meta-analysis
.
J Child Neurol
.
2016
;
31
(
9
):
1093
107
.
15.
Brigo
F
,
Nardone
R
,
Tezzon
F
,
Trinka
E
.
Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: a systematic review with meta-analysis
.
Epilepsy Behav
.
2015
;
49
:
325
36
.
16.
Cohen
NT
,
Chamberlain
JM
,
Gaillard
WD
.
Timing and selection of first antiseizure medication in patients with pediatric status epilepticus
.
Epilepsy Res
.
2019
;
149
:
21
5
.
17.
Lewena
S
,
Pennington
V
,
Acworth
J
,
Thornton
S
,
Ngo
P
,
McIntyre
S
.
Emergency management of pediatric convulsive status epilepticus: a multicenter study of 542 patients
.
Pediatr Emerg Care
.
2009
;
25
(
2
):
83
7
.
18.
Dalziel
SR
,
Borland
ML
,
Furyk
J
,
Bonisch
M
,
Neutze
J
,
Donath
S
.
Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial
.
Lancet
.
2019
;
393
(
10186
):
2135
45
.
19.
Lyttle
MD
,
Rainford
NEA
,
Gamble
C
,
Messahel
S
,
Humphreys
A
,
Hickey
H
.
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial
.
Lancet
.
2019
;
393
(
10186
):
2125
34
.
20.
Riviello
JJ
Jr
,
Claassen
J
,
LaRoche
S
,
Sperling
MR
,
Alldredge
B
,
Bleck
TP
.
Treatment of status epilepticus: an international survey of experts
.
Neurocrit Care
.
2013
;
18
(
2
):
193
200
.
21.
Chamberlain
JM
,
Kapur
J
,
Shinnar
S
,
Elm
J
,
Holsti
M
,
Babcock
L
.
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial [published correction appears in Lancet
.
Lancet
.
2020
;
395
(
10231
):
1217
24
.
22.
Min
L
,
Chunyan
W
,
Biaoxue
R
.
Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies
.
BMC Pediatr
.
2020
;
20
(
1
):
97
.
23.
Star
K
,
Edwards
IR
,
Choonara
I
.
Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase
.
PLoS One
.
2014
;
9
(
10
):
e108970
.
24.
Kravljanac
R
,
Djuric
M
,
Jankovic
B
,
Pekmezovic
T
.
Etiology, clinical course and response to the treatment of status epilepticus in children: a 16-year single-center experience based on 602 episodes of status epilepticus
.
Eur J Paediatr Neurol
.
2015
;
19
(
5
):
584
90
.
25.
Vossler
DG
,
Bainbridge
JL
,
Boggs
JG
,
Novotny
EJ
,
Loddenkemper
T
,
Faught
E
.
Treatment of refractory convulsive status epilepticus: a comprehensive review by the American epilepsy society treatments committee
.
Epilepsy Curr
.
2020
;
20
(
5
):
245
64
.
26.
Qadir
W
,
Wani
KA
,
Bhat
BA
.
Sociodemographic profile, semiology, and etiology of patients with status epilepticus: a study from a tertiary care hospital in north India
.
J Neurosci Rural Pract
.
2018
;
9
(
4
):
487
91
.
27.
Cobo
NH
,
Sankar
R
,
Murata
KK
,
Sewak
SL
,
Kezele
MA
,
Matsumoto
JH
.
The ketogenic diet as broad-spectrum treatment for super-refractory pediatric status epilepticus: challenges in implementation in the pediatric and neonatal intensive care units
.
J Child Neurol
.
2015
;
30
(
2
):
259
66
.
28.
Ferlisi
M
,
Shorvon
S
.
The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy
.
Brain
.
2012
135
Pt 8
2314
28
.
29.
Dubey
D
,
Pittock
SJ
,
Kelly
CR
,
McKeon
A
,
Lopez-Chiriboga
AS
,
Lennon
VA
.
Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis
.
Ann Neurol
.
2018
;
83
(
1
):
166
77
.
30.
Arayakarnkul
P
,
Chomtho
K
.
Treatment options in pediatric super-refractory status epilepticus
.
Brain Dev
.
2019
;
41
(
4
):
359
66
.
31.
Meletti
S
,
Monti
G
,
Mirandola
L
,
Vaudano
AE
,
Giovannini
G
.
Neuroimaging of status epilepticus
.
Epilepsia
.
2018
59
Suppl 2
113
9
.
32.
Mendes
A
,
Sampaio
L
.
Brain magnetic resonance in status epilepticus: a focused review
.
Seizure
.
2016
;
38
:
63
7
.
33.
Payne
ET
,
Zhao
XY
,
Frndova
H
,
McBain
K
,
Sharma
R
,
Hutchison
JS
.
Seizure burden is independently associated with short term outcome in critically ill children
.
Brain
.
2014
137
Pt 5
1429
38
.
34.
Abend
NS
,
Arndt
DH
,
Carpenter
JL
,
Chapman
KE
,
Cornett
KM
,
Gallentine
WB
.
Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality
.
Neurology
.
2013
;
81
(
4
):
383
91
.
35.
Sansevere
AJ
,
Hahn
CD
,
Abend
NS
.
Conventional and quantitative EEG in status epilepticus
.
Seizure
.
2019
;
68
:
38
45
.
36.
Liukkonen
E
,
Kantola-Sorsa
E
,
Paetau
R
,
Gaily
E
,
Peltola
M
,
Granström
ML
.
Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome
.
Epilepsia
.
2010
;
51
(
10
):
2023
32
.
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