Background: In individuals with Parkinson’s disease (PD), visually guided saccades (VGSs) reportedly reflect general motor dysfunction and cognitive impairments. However, it has not been fully elucidated whether the VGS abnormalities result from nigrostriatal degeneration or other PD-related neural changes. Methods: We measured VGS latency and gain in 50 PD participants and 56 age-matched normal controls (NCs), and PD participants underwent dopamine transporter (DAT) single-photon emission computed tomography (SPECT) within 2 months of the measurement. VGSs were evoked by a white dot on a monitor, which was presented at the center and pseudo-randomly jumped off horizontally (10° or 20° eccentricity) or vertically (10° or 15°). First, we compared the parameters between PD participants and NCs for each target location. Second, in the participants who exhibited striatal DAT asymmetry on SPECT, VGSs contralaterally directed to the more severely affected striatum were compared with those ipsilaterally directed. Third, effects of the DAT-SPECT specific binding ratio (SBR) on VGSs were analyzed. Results: PD participants demonstrated prolonged latencies when the target was presented at the upward 15° eccentricity and decreased gains at all target locations. Contralateral VGSs relative to the side of the more severely affected striatum were more delayed and hypometric than ipsilateral. The SBR had a significant positive effect on VGS gain. Conclusions: In participants with PD, saccadic abnormalities were emphasized when VGSs were directed contralaterally to the more severely affected striatum. Moreover, the dopaminergic nigrostriatal degeneration on DAT-SPECT was mainly associated with VGS gain.

1.
Leigh
RJ
,
Kennard
C
.
Using saccades as a research tool in the clinical neurosciences
.
Brain
.
2004 Mar
;
127
(
Pt 3
):
460
77
. .
2.
Bogousslavsky
J
,
Regli
F
.
Pursuit gaze defects in acute and chronic unilateral parieto-occipital lesions
.
Eur Neurol
.
1986
;
25
(
1
):
10
8
. .
3.
Vidailhet
M
,
Rivaud
S
,
Gouider-Khouja
N
,
Pillon
B
,
Bonnet
AM
,
Gaymard
B
, et al
Eye movements in parkinsonian syndromes
.
Ann Neurol
.
1994 Apr
;
35
(
4
):
420
6
. .
4.
Rottach
KG
,
Riley
DE
,
DiScenna
AO
,
Zivotofsky
AZ
,
Leigh
RJ
.
Dynamic properties of horizontal and vertical eye movements in parkinsonian syndromes
.
Ann Neurol
.
1996 Mar
;
39
(
3
):
368
77
. .
5.
Leigh
RJ
,
Zee
DS
.
Disorders of ocular motility with disease affecting the basal ganglia, cerebral cortex, and in systemic conditions
. In:
Leigh
RJ
,
Zee
DS
, editors.
The neurology of eye movements
. 5th ed, revised.
New York
:
Oxford University Press
;
2015
. p.
916
1023
.
6.
Visser
F
,
Bour
LJ
,
Lee
YX
,
Ten Brinke
TR
,
van Rootselaar
AF
.
Eye movement abnormalities in essential tremor versus tremor dominant Parkinson’s disease
.
Clin Neurophysiol
.
2019 May
;
130
(
5
):
683
91
. .
7.
Chambers
JM
,
Prescott
TJ
.
Response times for visually guided saccades in persons with Parkinson’s disease: a meta-analytic review
.
Neuropsychologia
.
2010 Mar
;
48
(
4
):
887
99
.
8.
Shaikh
AG
,
Xu-Wilson
M
,
Grill
S
,
Zee
DS
.
‘Staircase’ square-wave jerks in early Parkinson’s disease
.
Br J Ophthalmol
.
2011 May
;
95
(
5
):
705
9
. .
9.
Mosimann
UP
,
Müri
RM
,
Burn
DJ
,
Felblinger
J
,
O'Brien
JT
,
McKeith
IG
.
Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
.
Brain
.
2005 Jun
;
128
(
Pt 6
):
1267
76
. .
10.
Macaskill
MR
,
Graham
CF
,
Pitcher
TL
,
Myall
DJ
,
Livingston
L
,
van Stockum
S
, et al
The influence of motor and cognitive impairment upon visually-guided saccades in Parkinson’s disease
.
Neuropsychologia
.
2012 Dec
;
50
(
14
):
3338
47
. .
11.
Terao
Y
,
Fukuda
H
,
Yugeta
A
,
Hikosaka
O
,
Nomura
Y
,
Segawa
M
, et al
Initiation and inhibitory control of saccades with the progression of Parkinson’s disease – changes in three major drives converging on the superior colliculus
.
Neuropsychologia
.
2011 Jun
;
49
(
7
):
1794
806
. .
12.
Weil
RS
,
Schrag
AE
,
Warren
JD
,
Crutch
SJ
,
Lees
AJ
,
Morris
HR
.
Visual dysfunction in Parkinson’s disease
.
Brain
.
2016 Nov 1
;
139
(
11
):
2827
43
. .
13.
Terao
Y
,
Fukuda
H
,
Ugawa
Y
,
Hikosaka
O
.
New perspectives on the pathophysiology of Parkinson’s disease as assessed by saccade performance: a clinical review
.
Clin Neurophysiol
.
2013 Aug
;
124
(
8
):
1491
506
.
14.
Antonini
A
,
Benti
R
,
De Notaris
R
,
Tesei
S
,
Zecchinelli
A
,
Sacilotto
G
, et al
123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy
.
Neurol Sci
.
2003 Oct
;
24
(
3
):
149
50
.
15.
Booth
TC
,
Nathan
M
,
Waldman
AD
,
Quigley
AM
,
Schapira
AH
,
Buscombe
J
.
The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1
.
AJNR Am J Neuroradiol
.
2015 Feb
;
36
(
2
):
229
35
. .
16.
Tissingh
G
,
Bergmans
P
,
Booij
J
,
Winogrodzka
A
,
van Royen
EA
,
Stoof
JC
, et al
Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by (123I)beta-CIT SPECT
.
J Neurol
.
1998 Jan
;
245
(
1
):
14
20
.
17.
Ottaviani
S
,
Tinazzi
M
,
Pasquin
I
,
Nothdurfter
W
,
Tomelleri
G
,
Fincati
E
, et al
Comparative analysis of visual and semi-quantitative assessment of striatal (123I)FP-CIT-SPET binding in Parkinson’s disease
.
Neurol Sci
.
2006 Dec
;
27
(
6
):
397
401
. .
18.
Hughes
AJ
,
Daniel
SE
,
Kilford
L
,
Lees
AJ
.
Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases
.
J Neurol Neurosurg Psychiatry
.
1992 Mar
;
55
(
3
):
181
4
.
19.
Tossici-Bolt
L
,
Hoffmann
SM
,
Kemp
PM
,
Mehta
RL
,
Fleming
JS
.
Quantification of (123I)FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio
.
Eur J Nucl Med Mol Imaging
.
2006 Dec
;
33
(
12
):
1491
9
. .
20.
Matsuda
H
,
Murata
M
,
Mukai
Y
,
Sako
K
,
Ono
H
,
Toyama
H
, et al
Japanese multicenter database of healthy controls for [
.
Eur J Nucl Med Mol Imaging
.
2018 Jul
;
45
(
8
):
1405
16
. .
21.
R Foundation for Statistical Computing [Internet]. Vienna: R: A language and environment for statistical computing [accessed 22 September 2019]. Available from: https://www.r-project.org/.
22.
Kuznetsova
A
,
Brockhoff
PB
,
Christensen
RHB
.
lmer test package: tests in linear mixed effects models
.
J Stat Softw
.
2017
;
82
(
13
):
1
26
. .
23.
Kori
A
,
Miyashita
N
,
Kato
M
,
Hikosaka
O
,
Usui
S
,
Matsumura
M
.
Eye movements in monkeys with local dopamine depletion in the caudate nucleus. II. Deficits in voluntary saccades
.
J Neurosci
.
1995 Jan
;
15
(
1 Pt 2
):
928
41
. .
24.
Ventre
J
,
Zee
DS
,
Papageorgiou
H
,
Reich
S
.
Abnormalities of predictive saccades in hemi-Parkinson’s disease
.
Brain
.
1992 Aug
;
115
(
Pt 4
):
1147
65
. .
25.
Chan
F
,
Armstrong
IT
,
Pari
G
,
Riopelle
RJ
,
Munoz
DP
.
Deficits in saccadic eye-movement control in Parkinson’s disease
.
Neuropsychologia
.
2005
;
43
(
5
):
784
96
. .
26.
Kobayashi
M
.
Delayed saccade to perceptually demanding locations in Parkinson’s disease: analysis from the perspective of the speed-accuracy trade-off
.
Neurol Sci
.
2016 Nov
;
37
(
11
):
1841
8
.
27.
Abrams
J
,
Nizam
A
,
Carrasco
M
.
Isoeccentric locations are not equivalent: the extent of the vertical meridian asymmetry
.
Vision Res
.
2012
;
52
(
1
):
70
8
. .
28.
Choi
SM
,
Lee
SH
,
Choi
KH
,
Nam
TS
,
Kim
JT
,
Park
MS
, et al
Directional asymmetries of saccadic hypometria in patients with early Parkinson’s disease and unilateral symptoms
.
Eur Neurol
.
2011
;
66
(
3
):
170
4
. .
29.
Delinte
A
,
Gomez
CM
,
Decostre
MF
,
Crommelinck
M
,
Roucoux
A
.
Amplitude transition function of human express saccades
.
Neurosci Res
.
2002 Jan
;
42
(
1
):
21
34
. .
30.
van Stockum
S
,
MacAskill
MR
,
Anderson
TJ
.
Impairment of voluntary saccades and facilitation of reflexive saccades do not co-occur in Parkinson’s disease
.
J Clin Neurosci
.
2012 Aug
;
19
(
8
):
1119
24
. .
31.
McSorley
E
,
Findlay
JM
.
Saccade target selection in visual search: accuracy improves when more distractors are present
.
J Vis
.
2003 Dec
;
3
(
11
):
877
92
. .
32.
Sumner
P
.
Determinants of saccade latency
. In:
Liversedge
SP
,
Gilchrist
I
,
Everling
S
, editors.
The Oxford handbook of eye movements
.
Oxford
:
Oxford University Press
;
2011
. p.
413
24
.
33.
Pierrot-Deseilligny
C
.
Saccade and smooth-pursuit impairment after cerebral hemispheric lesions
.
Eur Neurol
.
1994
;
34
(
3
):
121
34
. .
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