Edgar Douglas Adrian was an outstandingly brilliant, Nobel prize-winning neurophysiologist. He is remembered for developing the all-or-none principle of muscle contraction, and for explaining the minutiae of motor and sensory nerve transmission. He showed that the afferent effect in a neuron depends on the pattern in time of the impulses travelling in it, thereby providing a quantitative basis of nervous behaviour. With Sir Charles Sherrington, he was awarded the Nobel Prize in 1932 for discoveries on the functions of the neurons.

Keywords:
Lord Adrian, Neurophysiologist, Nerve transmission, All or none principle, Refractory period
1.
Sharpey-Schafer E: Observations on the history of physiology in great britain during the last hundred years. BMJ 1932; 2: 781–783.
2.
Sharpey-Schafer E: History of the physiological society during its first fifty years, 1876–1926, Part 1. J Physiol 1927; 64(3 suppl):1–76.
3.
Nobel Lectures, Physiology or Medicine 1922–1941, Elsevier Publishing Company, Amsterdam, 1965. http://nobelprize.org/medicine/laureates/1932/adrian-bio.html.
4.
Hodgkin A: Edgar Douglas Adrian, Baron Adrian of Cambridge. Biographical Memoirs of Fellows of the Royal Society, 1979, pp 1–73.
5.
Adrian ED: The all-or-nothing reaction. Ergebnisse der Physiologie und experimentellen Pharmakologie 1933; 35: 744–755.
6.
McComas AJ: Galvani’s Spark: The Story of the Nerve Impulse. New York, Oxford Univ Press, 2011.
7.
Adrian ED, Yealland LR: The treatment of some common war neuroses. Lancet 1917; 17: 867–872.
8.
Hill AV: The Ethical Dilemma of Science, 1960.
9.
Sherrington CS: The integrative action of the nervous system. New York, C. Scribner’s Sons, 1906.
10.
Adrian ED: The basis of sensation; the action of the sense organs, by E.D. Adrian. London, Christophers, 1928.
11.
Adrian ED: The mechanism of nervous action; electrical studies of the neurone. Philadelphia, University of Pennsylvania Press, 1932.
12.
Adrian ED: The physical background of perception, Oxford, Clarendon Press, 1947.
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2017
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