Introduction: It is important to recognize acutely evolving ischemic stroke attributable to reactivation of varicella zoster virus vasculopathy since antiviral agents are effective. Methods: Three cases seen by the author over a 2-year period are highlighted. Results: All patients presented with an evolving arterial or venous ischemia in the background of postherpetic neuralgia proceeding for weeks to months. Conclusion: Chronic neuralgic pain in a dermatomal distribution of an evolving central nervous system vasculopathy is an important clue to its recognition.

1.
Nagel MA, Cohrs RJ, Mahalingham R, et al: The varicella zoster virus vasculopathies. Clinical, CSF, imaging, and virologic features. Neurology 2008;70:853–860.
2.
Gilden DH, Lipton HL, Wolf JS, et al: Two patients with unusual forms of varicella-zoster virus vasculopathy. N Engl J Med 2002;347:1500–1503.
3.
Gilden DH, Cohrs RJ, Hayward AR, Wellish M, Mahalingam R: Chronic varicella-zoster virus ganglionitis – a possible cause of postherpetic neuralgia. J Neurovirol 2003;9:404–407.
4.
Doyle BW, Gibeon G, Dolman CL: Herpes zoster ophthalmicus with contralateral hemiplegia: identification of cause. Ann Neurol 1983;14:84–85.
5.
Terada K, Niizuma T, Kawano S, et al: Detection of varicella-zoster virus DNA in peripheral mononuclear cells from patients with Ramsay hunt syndrome or zoster sine herpete. J Med Virol 1998;56:359–363.
6.
Blumenthal DT, Shacham-Shmueli E, Bokstein F, et al: Zoster sine herpete: virologic verification by detection of anti-VZV IgG antibody in CSF. Neurology 2011;76:484.
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