Music, as language, is a universal and specific trait to humans; it is a complex ability with characteristics that are unique compared to other cognitive abilities. Nevertheless, several issues are still open to debate, such as, for example, whether music is a faculty that is independent from the rest of the cognitive system, and whether musical skills are mediated by a single mechanism or by a combination of processes that are independent from one another. Moreover, the anatomical correlations of music have yet to be clarified. The goal of this review is to illustrate the current condition of the neuropsychology of music and to describe different approaches to the study of the musical functions. Hereby, we will describe the neuropsychological findings, suggesting that music is a special function carried out by different and dedicated processes that are probably subserved by different anatomical regions of the brain. Moreover, we will review the evidence obtained by working with brain-damaged patients suffering from music agnosia, a selective impairment in music recognition.

1.
Dalla Bella S, Peretz I: Music agnosias: selective impairments of music recognition after brain damage. J New Music Res 1999;28:209–216.
2.
Peretz I, Hyde K: What is specific to music processing? Insights from congenital amusia. Trends Cogn Sci 2003;8:362–367.
3.
Wallin NL, Merker B, Brown S (eds): The Origins of Music. Cambridge, MIT Press, 2000.
4.
Drake C: Psychological processes involved in the temporal organization of complex auditory sequences: universal and acquired processes. Music Percept 1998;16:11–26.
5.
Trehub SE: Human processing predispositions and musical universals; in Wallin NL, Merker B, Brown S (eds): The Origins of Music. Cambridge, MIT Press, 2000, pp 427–448.
6.
Peretz I, Morais J: Specificity for music; in Boller F, Grafman J (eds): Handbook of Neuropsychology. Amsterdam, Else, 1993, vol 8, pp 373–390.
7.
Beatty W, Zavadil K, Bailly R, Rixen G, Zavadil L, Farnham N, Fisher L: Preserved musical skill in a severely demented patient. Int J Clin Neuropsychol 1988;10:158–164.
8.
Hermelin B, O’Connor N, Lee S: Musical inventiveness of five idiot-savants. Psychol Med 1987;17:685–694.
9.
Dorgeuille C: Introduction à l’étude des amusies; unpubl doct diss, Paris 1966.
10.
Marin O: Neurological aspects of music perception and performance; in Deutsch D (ed): The Psychology of Music. New York, Academic Press, 1983.
11.
Piccirilli M, Sciarma T, Luzzi S: Modularity of music: evidence from a case of pure amusia. J Neurol Neurosurg Psychiatry 2000;69:541–545.
12.
Ayotte J, Peretz I, Rousseau I, Bard C, Bojanowski M: Patterns of music agnosia associated with middle cerebral artery infarcts. Brain 2000;123:1926–1938.
13.
Ayotte J, Peretz I, Hyde K: Congenital amusia. A group study of adults afflicted with a music-specific disorder. Brain 2002;125:238–251.
14.
Griffith T, Rees A, Witton C, Cross P, Shakir R, Green G: Spatial and temporal auditory processing deficits following right hemisphere infarction: a psychophysical study. Brain 1997;120:785–794.
15.
McFarland HR, Fortin D: Amusia due to right temporo-parietal infarct. Arch Neurol 1982;39:725–727.
16.
Peretz I: Brain specialization for music. Neuroscientist 2002;8:374–382.
17.
Steinke WR, Cuddy LL, Jakobson LS: Dissociations among functional subsystem governing melody recognition after right-hemisphere damage. Cogn Neuropsychol 2001;18:411–437.
18.
Wilson SJ, Pressing J: Neuropsychological assessment and the modeling of musical deficits; in Pratt RR, Erdonmez Grocke D (eds): Music Medicine and Music Therapy: Expanding Horizons. Melbourne, University of Melbourne, 1999, pp 47–74.
19.
Basso A: Amusia; in Boller F, Grafman J (eds): Handbook of Neuropsychology. Amsterdam, Elsevier Science, 1993, vol 8, pp 391–409.
20.
Basso A, Capitani E: Spared musical abilities in a conductor with global aphasia and ideomotor apraxia. J Neurol Neurosurg Psychiatry 1985;48:407–412.
21.
Mendez M: Generalized auditory agnosia with spared music recognition in a left-hander. Analysis of a case with a right temporal stroke. Cortex 2001;37:139–150.
22.
Signoret JL, Van Eeckhout P, Poncet M, Castaigne P: Aphasie sans amusie chez un organiste aveugle. Rev Neurol 1987;143:172–181.
23.
Peretz I: Music perception and recognition; in Rapp B (ed): The Handbook of Cognitive Neuropsychology. Hove, Psychology Press, 2001, pp 519–540.
24.
Peretz I, Kolinsky R, Tramo M, Labrecque R, Hublet C, Demeurisse G, Belleville S: Functional dissociations following bilateral lesions of auditory cortex. Brain 1994;117:1283–1301.
25.
Peretz I, Belleville S, Fontane S: Dissociations entre musique et langage après atteinte cérébrale: un nouveau cas d’amusie sans aphasie. Can J Exp Psychol 1997;51:354–368.
26.
Laignel-Lavastine M, Alajouanine T: Un cas d’agnosie auditive. Soc Neurol 1921;37:194–198.
27.
Peretz I, Coltheart M: Modularity of music processing. Nat Neurosci 2003;6:688–691.
28.
Ayotte J, Peretz I, Hyde K: Congenital amusia. A group study of adults afflicted with a music-specific disorder. Brain 2002;125:238–251.
29.
Schuppert M, Münte TF, Wieringa BM, Altenmüller E: Receptive amusia: evidence for cross-hemispheric neural networks underlying music processing strategies. Brain 2000;123:546–559.
30.
Grant-Allen: Note-deafness. Mind 1878;10:157–167.
31.
Dowling WJ: Melodic information processing and its development; in Deutsch D (ed): The Psychology of Music. New York, Academic Press, 1982, pp 413–429.
32.
Peretz I: Processing of local and global musical information by unilateral brain-damaged patients. Brain 1990;113:1185–1205.
33.
Zatorre RJ, Evans AC, Meyer E: Neural mechanism underlying melodic perception and memory for pitch. J Neurosci 1994;14:1908–1919.
34.
Liégeois-Chauvel C, Peretz I, Babaï M, Laguitton V, Chauvel P: Contribution of different cortical areas in the temporal lobes to music processing. Brain 1998;121:1853–1867.
35.
Zatorre RJ, Samson S: Role of the right temporal neocortex in retention of pitch in auditory shot-term memory. Brain 1991;114:2403–2417.
36.
Peretz I: Auditory agnosia: a functional analysis; in McAdams S, Bigand E (eds): Thinking in Sound. The Cognitive Psychology of Human Audition. Oxford, Clarendon Press, 1993, pp 199–230.
37.
Platel H, Price C, Baron JC, Wise R, Lambert J, Frackowiack RS, et al: The structural components of music perception. A functional anatomical study. Brain 1997;120:229–243.
38.
Barbizet J: Rôle de l’hémisphère droit dans les perceptions auditives; in Barbizet J, Ben Hamida M, Duizabo P (eds): Le Monde de l’Hémiplégie Gauche. Paris, Masson, 1972.
39.
Gardner H, Silverman J, Denes F, Semenza C, Rosentiel A: Sensitivity to musical denotation and connotation in organic patients. Cortex 1977;13:242–256.
40.
Zatorre RJ: Effects of temporal neocortical excisions on musical processing. Contemp Music Rev 1989;4:265–277.
41.
Gall FJ: Sur les fonctions du cerveau et sur celles de chacune de ses parties. Paris, Baillière, 1825.
42.
Bouillaud J: Sur la faculté du langage articulé. Bull Acad Natl Med 1865;30:752–768.
43.
Henschen SE: On the function of the right hemisphere of the brain in relation to the left in speech, music and calculation. Brain 1926;49:110–126.
44.
Milner B: Laterality effects in audition; in Mountcastle VB (ed): Interhemispheric Relations and Cerebral Dominance. Baltimore, Johns Hopkins, 1962.
45.
Shankweiler D: Effects of temporal-lobe damage on perception of dichotically presented melodies. J Comp Physiol Psychol 1966;62:115–119.
46.
Zatorre RJ: Discrimination and recognition of tonal melodies after unilateral cerebral excisions. Neuropsychologia 1985;23:31–41.
47.
Samson S, Zatorre RJ: Discrimination of melodic and harmonic stimuli after unilateral cerebral excisions. Brain Cogn 1988;7:348–360.
48.
Schulhoff C, Goodglass H: Dichotic listening, side of brain injury and cerebral dominance. Neuropsychologia 1969;7:149–160.
49.
Dowling WJ, Bartlett JC: The importance of interval information in long-term memory for melodies. Psychomusicology 1981;1:30–49.
50.
Povel DJ, Essens P: Perception of temporal patterns. Music Percept 1985;2:411–440.
51.
Kimura D: Cerebral dominance and the perception of verbal stimuli. Can J Psychol 1961;15:166–171.
52.
Kimura D: Left-right differences in the perception of melodies. Q J Exp Psychol 1964;16:355–358.
53.
Gordon HW: Hemispheric asymmetries in the perception of musical chords. Cortex 1970;6:387–398.
54.
Gordon HW: Left hemisphere dominance for rhythmic elements in dichotically presented melodies. Cortex 1978;14:58–70.
55.
Bartholomeus B: Effects of task requirements on ear superiority for sung speech. Cortex 1974;10:215–223.
56.
Gates A, Bradshaw JL: Music perception and cerebral asymmetries. Cortex 1977;13:390–401.
57.
Bever TG, Chiarello RJ: Cerebral dominance in musicians and non-musicians. Science 1974;185:137–139.
58.
Shanon B: Lateralization effects in musical decision tasks. Neuropsychologia 1980;18:21–31.
59.
Altenmuller O: How many music centers are in the brain? Ann NY Acad Sci 2001;930:273–280.
60.
Zatorre RJ, Halpern AR: Effect of unilateral temporal-lobe excision on perception and imagery of songs. Neuropsychologia 1993;31:221–232.
61.
Limb CJ, Braun AR: Neural substrates of spontaneous musical performance: an FMRI study of jazz improvisation. PLoS ONE 2008;3:e1679.
62.
Dietrich A: The cognitive neuroscience of creativity. Psychon Bull Rev 2004;11:1011–1026.
63.
Bengtsson SL, Csíkszentmihályi M, Ullén F: Cortical regions involved in the generation of musical structures during improvisation in pianists. J Cogn Neurosci 2007;19:830–842.
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