Abstract
In 20 patients who had suffered a first right hemisphere stroke, we examined the prevalence of double dissociations between the results of a star cancellation and a line bisection test. Both are common methods to assess spatial hemineglect. Within the group of neglect patients, we found no significant correlation between the two tasks. Furthermore, 5 patients with impaired performance on one of the tests were within the normal range on the other one. In agreement with experimental studies, we argue that spatial hemineglect is not a unitary syndrome. Furthermore, the findings in one of our patients are compatible with the view that an isolated deficit on cancellation tasks might follow from a lesion in the right anterior cingulate gyrus.
References
1.
Wilson B, Cockburn J, Halligan P: Behavioural Inattention Test. Bury St Edmunds, Thames Valley Test Company, 1987.
2.
Hillis AE, Caramazza A: A framework for interpreting distinct patterns of hemispatial neglect. Neurocase 1995;1:189–207.
3.
Marshall JC, Halligan PW, Robertson IH: Contemporary theories of unilateral neglect: A critical review; in Roberson IH, Marshall EJ (eds): Unilateral Neglect: Clinical and Experimental Studies. Hove, Erlbaum, 1993, pp 311–329.
4.
Karnath HO, Fetter M, Niemeier M: Disentangling gravitational, environmental, and egocentric reference frames in spatial neglect. J Cogn Neurosci 1998;10:680–690.
5.
Robertson LC, Eglin M: Attentional search in unilateral visual neglect; in Roberson IH, Marshall EJ (eds): Unilateral Neglect: Clinical and Experimental Studies. Hove, Erlbaum, 1993, pp 169–191.
6.
Heilman KM, Watson RT, Valenstein E: Neglect: Clinical and anatomic aspects; in Feinberg TE, Farah MJ (eds): Behavioral Neurology and Neuropsychology. New York, N.Y., McGraw-Hill, 1997, pp 309–317.
7.
Mattingley JB, Phillips JG, Bradshaw JL: Impairments of movement execution in unilateral neglect: A kinematic analysis of directional bradykinesia. Neuropsychologia 1994;32:1111–1134.
8.
Bisiach E, Geminiani G, Berti A, Rusconi ML: Perceptual and premotor factors of unilateral neglect. Neurology 1990;40:1278–1281.
9.
Binder J, Marshall R, Lazar R, Benjamin J, Mohr JP: Distinct syndromes of hemineglect. Arch Neurol 1992;49:1187–1194.
10.
Halligan PW, Marshall JC: The bisection of horizontal and radial lines: A case study of normal controls and ten patients with left visuo-spatial neglect. Int J Neurosci 1993;70:149–169.
11.
Kartsounis LD, Findley LJ: Task specific visuospatial neglect related to density and salience of stimuli. Cortex 1994;30:647–659.
12.
Marshall JC, Halligan PW: Within- and between-task dissociations in visuo-spatial neglect: A case study. Cortex 1995;31:367–376.
13.
Halligan PW, Marshall JC: Left visuo-spatial neglect: A meaningless entity? Cortex 1992;28:525–535.
14.
Schubert F: Assoziationen und Dissoziationen von visuellem Hemineglect und basalen Fähigkeiten der Raum- und Formerkennung bei Patienten mit rechtshirnigen Läsionen. Unveröff Dipl Arbeit, Universität Wien, 1998.
15.
Vallar G: The anatomical basis of spatial hemineglect in humans; in Roberson IH, Marshall EJ (eds): Unilateral Neglect: Clinical and Experimental Studies. Hove, Erlbaum, 1993.
16.
Heilman KM, Watson RT, Valenstein E: Neglect and related disorders; in Heilman KM, Valenstein E (eds): Clinical Neuropsychology. New York, Oxford University Press, 1985, pp 243–293.
17.
Mesulam MM: Spatial attention and neglect: Parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philos Trans R Soc Lond B Biol Sci 1999;29:1325–1346.
18.
Daffner KR, Ahern GL, Weintraub S, Mesulam MM: Dissociated neglect behavior following sequential strokes in the right hemisphere. Ann Neurol 1990;28:97–101.
19.
Warrington EK, James M: The Visual Object and Space Perception Battery. Bury St Edmunds, Thames Valley Test Company, 1991.
20.
Benton AL: Judgement of line orientation; in Benton AL, De Hamsher K, Spreen O (eds): Contributions to Neuropsychological Assessment. A Clinical Manual. New York, Oxford University Press, 1983.
21.
Denes G, Semenza C, Stoppa E, Lis A: Unilateral spatial neglect and recovery from hemiplegia: A follow-up study. Brain 1982;105:543–552.
22.
Halligan PW, Marshall JC, Wade DT: Visuospatial neglect: Underlying factors and test sensitivity. Lancet 1989;ii:908–911.
23.
Leibovitch FS, Black SE, Caldwell CB, Ebert PL, Ehrlich LE, Szalai JP: Brain-behavior correlations in hemispatial neglect using CT and SPECT: The Sunnybrook stroke study. Neurology 1998;50:901–908.
24.
Gitelman DR, Alpent NM, Kosslyn SM, Daffner K, Scinto L, Thompson W, et al: Functional imaging of human right hemispheric activation for exploratory movements. Ann Neurol 1996;39:174–179.
25.
Nobre AC, Sebestyen GN, Gitelman DR, Mesulam MM, Frackowiak RSJ, Frith CD: Functional localization of the system for visuospatial attention using positron emission tomography. Brain 1997;120:515–533.
26.
Procyk E, Tanaka YL, Joseph JP: Anterior cingulate activity during routine and non-routine sequential behaviors in macaques. Nat Neurosci 2000;3:502–508.
27.
Mesulam MM: From sensation to cognition. Brain 1998;121:1013–1052.
28.
Halligan PW, Marshall JC: Visuospatial neglect: The ultimate deconstruction? Brain Cogn 1998;37:419–438.
29.
Karnath HO: Spatial orientation and the representation of space with parietal lobe lesions. Philos Trans R Soc Lond B Biol Sci 1997;1360:1411–1419.
30.
Paus T: Location and function of the human frontal eye-field: A selective review. Neuropsychologia 1996;34:475–483.
31.
Petit L, Orssaud C, Tzourio N, Salamon G, Mazoyer B, Berthoz A: A PET study of voluntary saccadic eye movements in humans: Basal ganglia-thalamocortical system and cingulate cortex in involvement. J Neurophysiol 1993;69:1009–1017.
© 2001 S. Karger AG, Basel
2001
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