An intoxication by peroral and subcutaneous application of carbon tetrachloride was produced experimentally in 40 bastard rabbits. The pathohistological findings, especially in the nn. ischiadici, are described. The fine-tissue alterations of the myelin sheaths and axons and to a lesser extent in the neurilemma and the corresponding cerebro-spinal central spheres are evaluated as toxic polyneuropathies of a transition and mixed type. Since the nerves of the injected extremity were impaired most severely by subcutaneous application, the immediate operation of the toxic substance on the tissue by diffusion, with localized disturbance of metabolism, circulation, and ionic metabolism, is regarded as probable.The comparison of the findings in the two methods of intoxication with each other and with the control group proved to be partially significant.

Keywords:
CCl4 poisoning, Experimental neuropathy, Axon degeneration, Demyelination
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© 1973 S. Karger AG, Basel
1973
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