The histological and histochemical examinations of skeletal muscle biopsies of 120 patients with primary and neurogenic muscular diseases are discussed. The morphological changes observed, chiefly myopathic alterations and atrophy of muscle fibers, are generally nonspecific. The histological pattern and histochemical reactions in the altered muscle fibers, which are regenerating, splitting or necrotic, are similar in primary and in neurogenic muscular diseases. This is observed both in oxidative and in hydrolytic enzyme reactions. The differences found are mostly quantitative and concern mainly the frequency of these alterations. The nonspecific morphological changes which are the response of the muscle tissue to the various etiological affections, taken together, create a complex with an increased diagnostic value.

Keywords:
Neuromuscular diseases, Histological and histochemical features, Myopathic changes, Atrophic muscle fibers
This content is only available via PDF.
© 1973 S. Karger AG, Basel
1973
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.