..., respectively. AadAT-I demonstrated only glutamate-2-oxoadipate or 2-aminoadipate-2-oxoglutarate aminotransferase activities. AadAT-II further showed the activity of tryptophan and kynurenine. On the basis of K(m) values and subcellular localization of the isoenzymes, a plausible role was suggested for them...

...Seymour Kaufman The phenylalanine-hydroxylating system consists of 3 essential components,phenylalanine hydroxylase (PAH), dihydropteridine reductase (DHPR) and the coenzyme,tetrahydrobiopterin (BH(4)). DHPR and BH(4) are also essential components of the tyrosineand tryptophan-hydroxylating systems...

... in alterations in the synthesis and catabolism of neurotransmitters in the brain. In hyperammonemic rats, the uptake of tryptophan into the brain is increased with an augmented flux through the serotonin pathway. In the forebrain, glutamine as well as amino acids transported with the same L-carrier system...