... concentration occurring after 4 h, and was then cleared from the circulation with a half-life of 4.4 h. In marked contrast,when microencapsulated ʟ-asparaginase was injected, no significant ʟ-asparaginase activity appeared in the blood for the entire duration of this study. ‘Body’ ʟ-asparaginase levels declined...

...T.M.S. Chang L-Asparaginase from E. coli has been immobilized within semipermeable microcapsules which retain the enzyme and allow asparagine to enter the microcapsules to be acted on by the microencapsulated asparaginase. When stored in vitro at 4°C the microencapsulated asparaginase retained 90...