... of the perfused liver. The activities of cathepsins B, H and L were only slightly higher in the periportal than in the perivenous cell lysates. These results support the view that there is little zonation of lysosomal degradation of proteins, whereas the enzymatic capacity for degradation of glycosaminoglycans...

...Daniel Keppler; Bonnie F. Sloane Overexpression and altered trafficking of cathepsin B characterize the malignant phenotype of tumor cells. Human cathepsin B is encoded by a single-copy gene located on chromosome 8p22. With its 13 exons, the gene encompasses at least 27 kb of DNA. Expression...

...Santiago Santidrian; Elena Reyes; Mercedes Goena; Fernando Cuevillas; Jesus Larralde Total liver cathepsin A and D and gastrocnemius acid proteolytic activities have been evaluated in male growing rats fed ad libitum over periods of 15 and 30 days on 20%-protein diets containing either casein...

... of Skeletal Muscle in Rat l A. Jakubiec-Puka and W. Drabikowski21 Department of Biochemistry of Nervous System and Muscle, Nencki Institute of Experimental Biology, Warszawa Key Words. Cathepsins Skeletal muscle Denervation Reinnervation Abstract. Changes in the proteolytic activity and in the relative...

...N.C. Kar; C.M. Pearson Homogenates of human skeletal muscle showed autolytic and cathepsin activity over a wide pH range with peaks at 3.6, 6.6 and 8.6. Some evidence was presented for the enzymatic and proteolytic nature of the autolytic process. Both myoglobin and hemoglobin were equally active...

...Santiago Santidrian; Maria L. Rodriguez; Jesus Larralde As compared to well-nourished chickens, a significant reduction (p < 0.05) in the rate of growth, along with a significant increase (p < 0.05) in liver activities of both cathepsin A and D has been found in growing male chickens fed ad...