...Henri Rochefort; Emmanuelle Liaudet; Marcel Garcia Abstract Cathepsin D (Cath D) overexpression in breast cancer cells is associated with increased risk of metastasis in patients according to several clinical studies. The amino acid sequence of Cath D in two breast cancer cell lines was normal...

... form of the enzyme and also cathepsin D increased in the cytosol of both caput and cauda epididymis. This set of data demonstrates for the first time that a triggering mechanism which stimulates lysosomal activity is present all along the rat epididymis. Disposal of the continuous influx of spermatozoa...

...K. Wrogemann; B.E. Jacobson; M.C. Blanchaer Significant elevations were found in DNA, RNA,cathepsin D and β-glucuronidase in homogenates of the skeletal muscle of 30 polymyopathic hamsters of the BIO 14.6 strain, aged 250±9 days. However, the muscle content of collagen and non-collagen protein...

... of a sensitive fluorimetrie assay. The enzyme is similar to cathepsin D. The pentapeptides Z-Pro-Phe-His-Leu-Leu-β-naphthylamide and Z-Leu-Leu-Val-Tyr-Serß-naphthylamide were also attacked, but at a much slower rate. Smaller substrates were not hydrolyzed. The results indicate that the enzyme preferentially...