The application of the Freundlich equation suggested by Seegers et al. for the description of thrombin (EC 3.4.21.5) adsorption by fibrin is inadequate in that (i) an exception has to be assumed for the interpretation of the thrombin adsorption by fibrin at higher concentrations of thrombin, and (ii) no comprehensive reaction mechanism between thrombin and fibrin is further indicated by this suggestion. Existing data are shown to suggest an interpretation which (i) may provide an explanation for the existing data without irregularity and (ii) may have implications for the mechanism of thrombin equilibrium-binding to fibrin.

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