(1) Total protein concentration and tryptic inhibition was investigated in sow’s colostrum and milk and in the urine and serum of newborn piglets suckled at will or given colostrum or fetal serum orally or intravenously 10, 14 and 30 days after birth. (2) A close relationship was found between the occurrence of tryptic inhibition and the concentration of proteins in the urine in newborn piglets suckled at will and in the 10- and 30-day-old neonatal piglets given colostrum intravenously. (3) The protein fraction responsible for the tryptic inhibition in colostrum and urine was localized by casein-agarose gel electrophoresis to the γ-globulin region while in serum the dominating tryptic inhibition was localized to the α-globulin region. (4) The molecular weights of the colostrum and serum trypsin inhibitors were determined by Sephadex G-100 gel filtration and found to be 18,000 and 70,000, respectively. The conclusion can be drawn that any low molecular colostrum trypsin inhibitor which is present in serum is effectively excreted into the urine. (5) The transient neonatal proteinuria as indicated by changes in the colostrum trypsin inhibition in urine is probably not caused by drastic changes in the function of the porcine kidney at birth. The proteinuria is rather a consequence of temporarily high amounts of colostrum inhibitor and other low molecular colostrum proteins in the serum of the piglet.

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