Glycogen phosphorylase was determined both by measuring glycogen breakdown and glycogen synthesis in 7 adult rat tissues. Measurement in each direction confirmed the other as an adequate measure of the enzyme reaction (correlation coefficient= 0.997). The absolute rates were very different; but,relatively to liver as a reference tissue, the results of each assay in liver units agreed closely. The assays have similar precision. The assay based on the forward reaction has higher sensitivity. The more sensitive assay was used for enzyme determinations in several rat tumors. Phosphorylase is present in low amounts even in the highest-grade tumors.

Keywords:
Phosphorylase, Glycogen breakdown, Glycogen synthesis, Rat tissue, Rat tumor
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1972
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