Menschliche Galle hemmt die Aktivität von AP, GOT, GPT und G1DH stark, von LDH gering, nicht dagegen von G-6-PD. Die Inhibition wird durch Zusatz von Albumin aufgehoben, G1DH wird durch gleichzeitige Zugabe von Galle und Albumin aktiviert. Als Ursache von Inhibition und Aktivierung sind sterische Veränderungen am Enzymmolekül durch Einwirkung von Gallensäuren anzunehmen. Protein und Gallenfarbstoffe beeinflussen die Enzymaktivität nicht.

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