In isolierten Leukozyten aus Vollblut und Liquor wurden die Aktivitäten folgender Enzyme bestimmt: Hexokinase (HK), Glukose-6-Phos phatdehydrogenase (G-6-PDH), Aldolase, Glyceraldehydphosphatdehydrogenase (GAPDH), Lactatdehydrogenase (LDH), Malatdehydrogenase und Glutamat- Oxalacetat-Transaminase. Unter Berücksichtigung des prozentualen Anteils der Lymphozyten zeigen Vergleiche der Blut- und Liquorleukozyten, daß die zur Isolierung der Blutleukozyten verwendete Methode die untersuchten Enzymaktivitäten nicht verändert. Es bestehen keine Differenzen der Enzymaktivitäten bei Kindern verschiedenen Alters. Die Aktivität der G-6-PDH in Lymphozyten beträgt nur 11% derjenigen in Granulozyten; hierin sind auch die Aktivitäten der GAPDH und HK stärker vermindert, die der LDH dagegen nicht. Die G-6-PDH-Aktivität der Leukozyten bei Virusinfektionen ist nicht nur infolge des höheren Lymphozytenanteils, sondern vermutlich auch infolge einer virusbedingten Einwirkung auf den Zellmetabolismus vermindert.

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