... Adrenocorticotrophic hormone Opioids Hypogonadism Cocaine is the most popular illicit stimulant drug in Europe, especially amongst men, who are six times more likely than women to seek treatment for chronic cocaine use [ 1 ]. This gender discrepancy has been attributed to the endocrine actions of cocaine...

... data derived from a cue-reactivity task administered in persons with and without ESU and specific PET/SPECT receptor probability maps. Results: The endogenous mu-opioid receptor (MOR) system was found to be significantly (FDR-corrected) correlated with fMRI data, and z-transformed correlation...

...Gordon Ward Fuller; Matthew Jones; Ceri Anne Bradshaw; Jenna Jones; Ann John; Helen Snooks; Alan Watkins Background: Fatal opioid overdose is a significant public health problem with increasing incidence in developed countries. This study aimed to describe demographic and service user...

... naloxone is now being introduced in Europe. Despite evidence of the effectiveness and cost-effectiveness of THN, little is known about the attitudes of key target populations: people who use opioids (PWUO), family/friends, and staff. We examined the acceptability of different naloxone devices (ampoule...

...Jan van Amsterdam; Wim van den Brink; Mimi Pierce Backgrounds: Between 2009 and 2018, the number of opioid-related deaths (ORDs) in Scotland showed a dramatic increase, whereas in England and Wales, a much lower increase in ORD was seen. This regional difference is remarkable, and the situation...

... to be a significant problem and implicated in increased numbers of overdose cases. Vancouver, Toronto, and New York also reported significant wait times for addiction and psychiatric services and had the most limited range of opioid-assisted treatments available, largely focused on methadone and buprenorphine...

.... COVID-19 Economic recession High-risk drug use Substance abuse Opioids Editorial Eur Addict Res 2021;27:239 241 DOI: 10.1159/000513883 Received: September 18, 2020 Accepted: November 27, 2020 Published online: January 21, 2021 The Double Effect of COVID-19 Confinement Measures and Economic...

... with the newborns of opioid-exposed mothers and of mothers from the general population (GP). Method: A cohort study using nationwide registries in Czechia (2000–2014). Women hospitalized with a main diagnosis of MA use disorder during pregnancy ( n = 258) and their newborns were defined as MA-exposed...

...Carlos Nordt; Lucas Wiessing; Wil Kuijpers; Jeroen Wisselink; Albert Espelt; M. Teresa Brugal; Viktor Mravčik; Blanka Nechanská; Erich Seifritz; Marcus Herdener Heroin users in opioid agonist treatment (OAT) show markedly reduced heroin consumption, less crime and a lower mortality rate. However...

...Michael Soyka; Jens Strehle; Jürgen Rehm; Gerhard Bühringer; Hans-Ulrich Wittchen Background: In many countries, the opioid agonists, buprenorphine and methadone, are licensed for maintenance treatment of opioid dependence. Many short-term studies have been performed, but little is known about long...

... (as an opioid maintenance drug) and tramadol were the most frequently reported. Depending on their level of use in each country, methylphenidate, morphine and flunitrazepam presented the highest falsification ratios, particularly in Spain, Belgium and France. Conclusions: Stimulants, opioids and some...

...Pier Paolo Pani; Icro Maremmani; Matteo Pacini; Francesco Lamanna; Angelo G.I. Maremmani; Liliana dell’Osso While psychiatric comorbidity has been shown to produce a negative impact on the outcome of opioid use disorders, longitudinal studies carried out in the context of methadone maintenance...

...Jiri Modestin; Harald Rigoni Three groups of female inpatients were compared with each other with regard to criminal behavior: 51 patients with alcohol dependence, 39 patients with drug (mostly opioid) dependence and 488 patients not fulfilling DSM-IV criteria for substance dependence. 45...