...Hugo López-Pelayo; Anna Coma; Antoni Gual; Corinne Zara; Anna Lligoña Objective: Benzodiazepines have a good safety profile. Nevertheless, off-label use of these drugs may increase the risk of falls, dependence, and memory loss. Off-label prescription use is not highly prevalent. Studies have...

.... Benzodiazepines are the main substances for AWS in the USA [ 13 ]. They have anxiolytic, sedative-hypnotic, anticonvulsant, and muscle-relaxant properties [ 14 ] and act mainly by reinforcing inhibitory effects on the GABA-A receptor [ 15 ]. Diazepam has an elimination half-life of >24 h [ 14...

...Gudrun Høiseth; Gerrit Middelkoop; Jørg Mørland; Hallvard Gjerde Background and Aims: For many years, flunitrazepam was the benzodiazepine of choice among users of illegal drugs. The aim of this study was to investigate to which extent clonazepam use has increased in this population, and whether...

.... A falsification ratio was calculated by dividing the number of reports by the number of defined daily doses per 1,000 inhabitants per day for this drug, computed from national sale or reimbursement data. Results: On 862 prescription forms, benzodiazepines (zolpidem, bromazepam, alprazolam), buprenorphine...

...Walter de Millas; Florian Ganzer; Silke Kuhn; Christian Haasen The pharmacological management of the alcohol withdrawal syndrome associated with alcohol dependence is heterogeneous; however, according to the guidelines, clomethiazol is the standard medication in Germany. Benzodiazepines offer...

... and the capacity of general practitioners to prescribe opioids in adequate doses with a minimum of concomitant benzodiazepine prescriptions. Methods: This study compares prescriptions for opioid maintenance and concomitant benzodiazepine from Viennese physicians in 2002 and 2005 using health insurance prescription...