Background: In the motivational model of alcohol use, there are two dimensions underlying the classification of drinking motives resulting in four drinking motive categories: enhancement, social, coping, and conformity motives. Methods: Using confirmatory factor analysis, the current study provides evidence on the best fitting factor structure in a large representative general population study among adults in the Netherlands (n = 2,440; two data waves separated by 3 months) using the DMQ-R (Drinking Motives Questionnaire Revised). Results: The four-factor structure had the best fit at both time points in comparison with any other solution. Test-retest reliabilities indicate individual motive change in level over time, but not in terms of the four-factor structure. Conclusion: The results replicate and extend previous findings among adolescents, in line with the motivational model of alcohol use, and suggest the utility of using the DMQ-R in future studies on adults’ drinking motives.