...Jan Balldin; Kaj Blennow; Görel Bråne; C.G. Gottfries; Ingvar Karlsson; Björn Regland; Anders Wallin In 40 patients with Alzheimer's disease (AD, <65 years), 56 patients with senile dementia of the Alzheimer type (SDAT, ≥65 years) and 45 patients with vascular dementia (VAD), basal cortisol...

... disease, but its prevalence in non-Alzheimer dementias in Caucasian populations is unknown. We found that the frequency of the apoE Ε4 allele was 0.45 in 93 Alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the frontal type patients, and 0.18 in 51 elderly...

... are not demented. We found in 9 cases of vascular dementia of Binswanger type a significant reduction in synaptophysin immunoreactivity of the cortical neuropil (9.1 %), the magnitude of which was not much less than in Alzheimer type dementia (10.9 %). These results suggest that a reduction in cortical synaptic...

... in a material consisting of 23 patients with early-onset AD (EAD), 31 with late-onset AD (LAD), 16 with frontal-lobe dementia (FLD), 25 with vascular dementia (VAD) and 25 controls. CSF-apoE was decreased in all of EAD (1.8 ± 1.1 mg/l; p < 0.0005), LAD(2.5 ± 0.9mg/l; p < 0.0005),VAD (2.3 ± 1.4mg/l; p...

... levels, the controls (n = 39) differed significantly from the patients with vascular dementia (n = 20; p < 0.05), senile dementia of the Alzheimer type (n = 29; p < 0.05), and ''pure'' Alzheimers disease (n = 8; p < 0.05), but not from those with frontal lobe dementia (n = 5). © 1996 S. Karger...

...Gunilla Hansson; Irina Alafuzoff; Bengt Winblad; Jan Marcusson Pre- and postsynaptic elements of the 5-hydroxytryptamine (5-HT, serotonin) system were studied in a control group and in patients with vascular dementia (VAD). The 5-HT uptake site was used as a presynaptic marker for 5-HT terminals...

...H. Hampel; F. Müller-Spahn; C. Berger; A. Haberl; M. Ackenheil; C. Hock Serum and cerebrospinal fluid (CSF) from 44 patients with clinical probable Alzheimer''s disease (AD) (subdivided in two groups with 18 early onset, EO, and 26 late onset, LO, cases), 10 patients with vascular dementia (VD...

... therapy among vascular dementia patients. Neurological and cognitive status were quantified among 22 demented patients with small strokes and compared with 22 age-matched normal volunteers. In vascular dementia, risk factor control plus antiplatelet therapy reduced cerebral infarctions, increased...

...Johan Gottfries; Kaj Blennow; Anders Wallin; C.G. Gottfries Twenty patients with Alzheimers disease (AD), 34 with senile dementia of the Alzheimer type (SDAT) and 12 with vascular dementia (VAD) were carefully investigated. The diagnoses were made according to the DSM-III-R criteria and for AD/SDAT...

...Barbro B. Johansson In spite of the fact that hypertension is the main risk factor for cerebrovascular disease, retrospective studies have not given a clear answer concerning the role of hypertension in vascular dementia. Hypertension predisposes to intracerebral and extracerebral arterial...

...Ingmar Skoog In recent years, interest in vascular causes of dementia has increased and it has been proposed that vascular dementia (VAD) may be more common than previously supposed. This may have important implications, because VAD at present may be more amenable to prevention and treatment than...

.... Dementia Vascular disease Vascular dementia Multi-infarct dementia Dementia 1994;5:133-136 Michael D. O ßrien How Does Cerebrovascular Department of Neurology. Guy s Hospital. London, UK Disease Cause Dementia? Keywords Dementia Vascular disease Vascular dementia Multi-infarct dementia Abstract...

..., i.e. the term vascular dementia is clearly defined. Furthermore, the criteria of the ICD-10 allow a differentiation of vascular dementia into subtypes (vascular dementia of acute onset, multi-infarct dementia, subcortical vascular dementia, and mixed or unspecified types). The clinical feasibility...

...Timo Erkinjuntti Vascular dementia (VAD) is the second most common cause of dementia. In addition, cerebrovascular disease (CVD) coexists with other causes, including Alzheimer''s disease. Cognitive impairment related to CVD may be preventable, and these patients could benefit from therapy...

...Lars-Olof Wahlund Computed X-ray tomography and magnetic resonance imaging are two imaging modalities widely used in the evaluation of patients with dementia disorders. The role of the methods in relation to vascular dementia is discussed as well as their physical and clinical differences. Moreover...

...Wei Wei Zhang; Tichomir Badonic; Anders Höög; Ming Hui Jiang; Kuo Chun Ma; Jing Xiao Nie; Yngve Olsson; Patrick Sourander The condition of the brain parenchyma in cases of vascular dementia and other cerebrovascular conditions may be influenced by structural and functional changes of the terminal...

...Michael G. Hennerici; Manfred Oster; Simon Cohen; Andreas Schwartz; Lillian Motsch; Michael Daffertshofer The objective of this study was to correlate clinical and brain imaging findings with walking inabilities in patients with possible vascular dementia. For 24 patients with suspected initial...

...Vladimir Hachinski ‘Vascular dementia’ may be the leading cause of cognitive impairment in the world, yet there is little agreement as to what this concept encompasses or how it is defined. A critical review reaches the conclusion that the concept of ‘vascular dementia’ has become obsolete...

...Ove Almkvist The hypothesis that vascular dementia (VAD) may be associated with a specific pattern of neuropsychological dysfunction as compared to Alzheimer''s disease (AD) is reviewed. The empirical findings were evaluated with regard to methodology, most importantly the comparability between...

...C.G. Gottfries; K. Blennow; I. Karlsson; A. Wallin Vascular dementia (VAD) is cognitive impairment caused by changes in the blood circulation of the brain. It is not synonymous with multi-infarct dementia. The latter is a subgroup of VAD. Neurochemical investigations of noninfarcted brain tissue...