...Janice Robertson; Thérêse L.F Loviny; Michel Goedert; Ross Jakes; Kenneth J. Murray; Brian H. Anderton; Diane P. Hanger Alzheimer's disease paired helical filaments contain abnormally phosphorylated tau (PHF-tau) which has reduced electrophoretic mobility on sodium dodecyl sulphate polyacrylamide...

...Maho Morishima; Yasuo Ihara Paired helical filaments (PHF) are fibrillar structures that accumulate in degenerating neurons of AD brain. We have purified their components, PHF-tau and PHF-smear, and analyzed them proteinchemically. PHF-tau is abnormally phosphorylated. Although the characteristic...

...Takemi Kimura; Tsunehiko Ono; Junichi Takamatsu; Hideyuki Yamamoto; Ken Ikegami; Akira Kondo; Masato Hasegawa; Yasuo Ihara; Eishichi Miyamoto; Taihei Miyakawa It has been reported that many tau sites in neurofibrillary tangles (NFT) are abnormally phosphorylated. We investigated the phosphorylation...

... processes: (1) the production of abnormal forms of tau leading to the formation of cellular neurofibrillary tangles and neuropil threads; (2) the processing of the amyloid precursor protein, resulting in the formation of β-amyloid deposits and senile plaques, and (3) that via the mutual histocompatibility...

... significance is less well understood. Breakdown of the cytoskeleton may be involved in the progression from compromise of neuronal viability to irreversible damage. Alteration of the microtubule-associated protein tau, as reflected by increased Alz-50 immunoreactivity, was induced by permanent focal cerebral...

... by immunostaining with antibodies against neurofilaments, tau, ubiquitin, and paired-helical filaments (PHF) as well as by electron microscopy. Vacuolar or spongioform degeneration was minimum. Intense positive staining by antibodies against neurofilament 200K protein was demonstrated in neuronal perikarya...